E
Eitan Yaffe
Researcher at Stanford University
Publications - 21
Citations - 4935
Eitan Yaffe is an academic researcher from Stanford University. The author has contributed to research in topics: Genome & Biology. The author has an hindex of 11, co-authored 18 publications receiving 4294 citations. Previous affiliations of Eitan Yaffe include Tel Aviv University & Veterans Health Administration.
Papers
More filters
Journal ArticleDOI
Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome
Tom Sexton,Eitan Yaffe,Ephraim Kenigsberg,Frédéric Bantignies,Benjamin Leblanc,Michael Hoichman,Hugues Parrinello,Amos Tanay,Giacomo Cavalli +8 more
TL;DR: A high-resolution chromosomal contact map derived from a modified genome-wide chromosome conformation capture approach applied to Drosophila embryonic nuclei is presented, laying the foundation for detailed studies of chromosome structure and function in a genetically tractable system.
Journal ArticleDOI
Single-cell Hi-C reveals cell-to-cell variability in chromosome structure
Takashi Nagano,Yaniv Lubling,Tim J. Stevens,Stefan Schoenfelder,Eitan Yaffe,Wendy Dean,Ernest D. Laue,Amos Tanay,Peter Fraser +8 more
TL;DR: Single-cell Hi-C data bridge current gaps between genomics and microscopy studies of chromosomes, demonstrating how modular organization underlies dynamic chromosome structure, and how this structure is probabilistically linked with genome activity patterns.
Journal ArticleDOI
Probabilistic modeling of Hi-C contact maps eliminates systematic biases to characterize global chromosomal architecture
Eitan Yaffe,Amos Tanay +1 more
TL;DR: Analysis of corrected human lymphoblast contact maps provides genome-wide evidence for interchromosomal aggregation of active chromatin marks, including DNase-hypersensitive sites and transcriptionally active foci.
Journal ArticleDOI
Cohesin‐mediated interactions organize chromosomal domain architecture
Sevil Sofueva,Eitan Yaffe,Wen-Ching Chan,Dimitra Georgopoulou,Matteo Vietri Rudan,Hegias Mira-Bontenbal,Steven M. Pollard,Gary P. Schroth,Amos Tanay,Suzana Hadjur +9 more
TL;DR: It is shown that very specific long‐range interactions are anchored by cohesin/CTCF sites, but not cohes in‐only or CTCF‐only sites, to form a hierarchy of chromosomal loops.
Journal ArticleDOI
Comparative analysis of DNA replication timing reveals conserved large-scale chromosomal architecture.
Eitan Yaffe,Shlomit Farkash-Amar,Andreas Polten,Zohar Yakhini,Zohar Yakhini,Amos Tanay,Itamar Simon +6 more
TL;DR: It is shown that replication timing is remarkably conserved between human and mouse, uncovering large regions that may have been governed by similar replication dynamics since these species have diverged.