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Ekaterina A. Khramtsova
Researcher at University of Chicago
Publications - 23
Citations - 2267
Ekaterina A. Khramtsova is an academic researcher from University of Chicago. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 12, co-authored 19 publications receiving 1359 citations. Previous affiliations of Ekaterina A. Khramtsova include University of Illinois at Chicago & Janssen Pharmaceutica.
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Journal ArticleDOI
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
Phil Lee,Verneri Anttila,Hyejung Won,Yen-Chen Anne Feng,Jacob Rosenthal,Zhaozhong Zhu,Elliot M. Tucker-Drob,Michel G. Nivard,Andrew D. Grotzinger,Danielle Posthuma,Meg M.-J. Wang,Dongmei Yu,Eli A. Stahl,Raymond K. Walters,Richard Anney,Laramie E. Duncan,Tian Ge,Rolf Adolfsson,Tobias Banaschewski,Sintia Iole Belangero,Edwin H. Cook,Giovanni Coppola,Eske M. Derks,Pieter J. Hoekstra,Jaakko Kaprio,Anna Keski-Rahkonen,George Kirov,George Kirov,Henry R. Kranzler,Jurjen J. Luykx,Luis Augusto Rohde,Clement C. Zai,Esben Agerbo,Maria Arranz,Philip Asherson,Marie Bækvad-Hansen,Gisli Baldursson,Mark A. Bellgrove,Richard A. Belliveau,Jan K. Buitelaar,Christie L. Burton,Jonas Bybjerg-Grauholm,Miquel Casas,Felecia Cerrato,Kimberly Chambert,Claire Churchhouse,Bru Cormand,Jennifer Crosbie,Søren Dalsgaard,Ditte Demontis,Alysa E. Doyle,Ashley Dumont,Josephine Elia,Jakob Grove,Olafur O Gudmundsson,Jan Haavik,Hakon Hakonarson,Christine Søholm Hansen,Catharina A. Hartman,Ziarih Hawi,Amaia Hervás,David M. Hougaard,Daniel P. Howrigan,Hailiang Huang,Jonna Kuntsi,Kate Langley,Klaus-Peter Lesch,Patrick W. L. Leung,Sandra K. Loo,Joanna Martin,Alicia R. Martin,James J. McGough,Sarah E. Medland,Jennifer L. Moran,Ole Mors,Preben Bo Mortensen,Robert D. Oades,Duncan S. Palmer,Carsten Bøcker Pedersen,Marianne Giørtz Pedersen,Triinu Peters,Timothy Poterba,Jesper Buchhave Poulsen,Josep Antoni Ramos-Quiroga,Andreas Reif,Marta Ribasés,Aribert Rothenberger,Paula Rovira,Cristina Sánchez-Mora,F. Kyle Satterstrom,Russell Schachar,María Soler Artigas,Stacy Steinberg,Hreinn Stefansson,Patrick Turley,G. Bragi Walters,Thomas Werge,Tetyana Zayats,Dan E. Arking,Francesco Bettella,Joseph D. Buxbaum,Jane H. Christensen,Ryan L. Collins,Hilary Coon,Silvia De Rubeis,Richard Delorme,Dorothy E. Grice,Thomas Hansen,Peter Holmans,Sigrun Hope,Christina M. Hultman,Lambertus Klei,Christine Ladd-Acosta,Páll Magnússon,Terje Nærland,Mette Nyegaard,Dalila Pinto,Per Qvist,Karola Rehnström,Abraham Reichenberg,Jennifer Reichert,Kathryn Roeder,Guy A. Rouleau,Evald Saemundsen,Stephen Sanders,Sven Sandin,Beate St Pourcain,Kari Stefansson,James S. Sutcliffe,Michael E. Talkowski,Lauren A. Weiss,A. Jeremy Willsey,Ingrid Agartz,Huda Akil,Diego Albani,Martin Alda,Thomas Damm Als,Adebayo Anjorin,Lena Backlund,Nicholas Bass,Michael Bauer,Bernhard T. Baune,Frank Bellivier,Sarah E. Bergen,Wade H. Berrettini,Joanna M. Biernacka,Douglas Blackwood,Erlend Bøen,Monika Budde,William E. Bunney,Margit Burmeister,William Byerley,Enda M. Byrne,Sven Cichon,Toni-Kim Clarke,Jonathan R. I. Coleman,Nicholas John Craddock,David Curtis,Piotr M. Czerski,Anders M. Dale,Nina Dalkner,Udo Dannlowski,Franziska Degenhardt,Arianna Di Florio,Torbjørn Elvsåshagen,Bruno Etain,Sascha B. Fischer,Andreas J. Forstner,Liz Forty,Josef Frank,Mark A. Frye,Janice M. Fullerton,Katrin Gade,Helena Gaspar,Elliot S. Gershon,Michael Gill,Fernando S. Goes,Scott D. Gordon,Katherine Gordon-Smith,Melissa J. Green,Tiffany A. Greenwood,Maria Grigoroiu-Serbanescu,Jose Guzman-Parra,Joanna Hauser,Martin Hautzinger,Urs Heilbronner,Stefan Herms,Per Hoffmann,Dominic Holland,Stéphane Jamain,Ian Jones,Lisa Jones,Radhika Kandaswamy,John R. Kelsoe,James L. Kennedy,Oedegaard Ketil Joachim,Sarah Kittel-Schneider,Manolis Kogevinas,Anna C. Koller,Catharina Lavebratt,Cathryn M. Lewis,Qingqin S. Li,Jolanta Lissowska,Loes M. Olde Loohuis,Susanne Lucae,Anna Maaser,Ulrik Fredrik Malt,Nicholas G. Martin,Lina Martinsson,Susan L. McElroy,Francis J. McMahon,Andrew McQuillin,Ingrid Melle,Andres Metspalu,Vincent Millischer,Philip B. Mitchell,Grant W. Montgomery,Gunnar Morken,Derek W. Morris,Bertram Müller-Myhsok,Niamh Mullins,Richard M. Myers,Caroline M. Nievergelt,Merete Nordentoft,Annelie Nordin Adolfsson,Markus M. Nöthen,Roel A. Ophoff,Michael John Owen,Sara A. Paciga,Carlos N. Pato,Michele T. Pato,Roy H. Perlis,Amy Perry,James B. Potash,Céline S. Reinbold,Marcella Rietschel,Margarita Rivera,Mary Roberson,Martin Schalling,Peter R. Schofield,Thomas G. Schulze,Laura J. Scott,Alessandro Serretti,Engilbert Sigurdsson,Olav B. Smeland,Eystein Stordal,Fabian Streit,Jana Strohmaier,Thorgeir E. Thorgeirsson,Jens Treutlein,Gustavo Turecki,Arne E. Vaaler,Eduard Vieta,John B. Vincent,Yunpeng Wang,Stephanie H. Witt,Peter P. Zandi,Roger A.H. Adan,Lars Alfredsson,Tetsuya Ando,Harald N. Aschauer,Jessica H. Baker,Vladimir Bencko,Andrew W. Bergen,Andreas Birgegård,Vesna Boraska Perica,Harry Brandt,Roland Burghardt,Laura Carlberg,Matteo Cassina,Maurizio Clementi,Philippe Courtet,Steven Crawford,Scott J. Crow,James J. Crowley,Unna N. Danner,Oliver S. P. Davis,Daniela Degortes,Janiece E. DeSocio,Danielle M. Dick,Christian Dina,Elisa Docampo,Karin Egberts,Stefan Ehrlich,Thomas Espeseth,Fernando Fernández-Aranda,Manfred M. Fichter,Lenka Foretova,Monica Forzan,Giovanni Gambaro,Ina Giegling,Fragiskos Gonidakis,Philip Gorwood,Monica Gratacos Mayora,Yiran Guo,Katherine A. Halmi,Konstantinos Hatzikotoulas,Johannes Hebebrand,Sietske G. Helder,Beate Herpertz-Dahlmann,Wolfgang Herzog,Anke Hinney,Hartmut Imgart,Susana Jiménez-Murcia,Craig Johnson,Jennifer Jordan,Antonio Julià,Deborah Kaminská,Leila Karhunen,Andreas Karwautz,Martien J H Kas,Walter H. Kaye,Martin A. Kennedy,Youl-Ri Kim,Lars Klareskog,Kelly L. Klump,Gun Peggy Knudsen,Mikael Landén,Stephanie Le Hellard,Robert D. Levitan,Dong Li,Paul Lichtenstein,Mario Maj,Sara Marsal,Sara McDevitt,James R. Mitchell,Palmiero Monteleone,Alessio Maria Monteleone,Melissa A. Munn-Chernoff,Benedetta Nacmias,Marie Navratilova,Julie K. O'Toole,Leonid Padyukov,Jacques Pantel,Hana Papezova,Raquel Rabionet,Anu Raevuori,Nicolas Ramoz,Ted Reichborn-Kjennerud,Valdo Ricca,Marion Roberts,Dan Rujescu,Filip Rybakowski,André Scherag,Ulrike Schmidt,Jochen Seitz,Lenka Slachtova,Margarita C T Slof-Op 't Landt,Agnieszka Słopień,Sandro Sorbi,Lorraine Southam,Michael Strober,Alfonso Tortorella,Federica Tozzi,Janet Treasure,Konstantinos Tziouvas,Annemarie A. van Elburg,Tracey D. Wade,Gudrun Wagner,Esther Walton,Hunna J. Watson,H-Erich Wichmann,D. Blake Woodside,Eleftheria Zeggini,Stephanie Zerwas,Stephan Zipfel,Mark Adams,Till F. M. Andlauer,Klaus Berger,Elisabeth B. Binder,Dorret I. Boomsma,Enrique Castelao,Lucía Colodro-Conde,Nese Direk,Anna R. Docherty,Enrico Domenici,Katharina Domschke,Erin C. Dunn,Jerome C. Foo,E.J.C. de Geus,Hans J. Grabe,Steven P. Hamilton,Carsten Horn,Jouke-Jan Hottenga,David M. Howard,Marcus Ising,Stefan Kloiber,Douglas F. Levinson,Glyn Lewis,Patrik K. E. Magnusson,Hamdi Mbarek,Christel M. Middeldorp,Sara Mostafavi,Dale R. Nyholt,Brenda W.J.H. Penninx,Roseann E. Peterson,Giorgio Pistis,David J. Porteous,Martin Preisig,Jorge A. Quiroz,Catherine Schaefer,Eva C. Schulte,Jianxin Shi,Daniel J. Smith,Pippa A. Thomson,Henning Tiemeier,Rudolf Uher,Sandra Van der Auwera,Myrna M. Weissman,Madeline Alexander,Martin Begemann,Elvira Bramon,Nancy G. Buccola,Murray J. Cairns,Dominique Campion,Vaughan J. Carr,C. Robert Cloninger,David Cohen,David A. Collier,Aiden Corvin,Lynn E. DeLisi,Gary Donohoe,Frank Dudbridge,Jubao Duan,Robert B. Freedman,Pablo V. Gejman,Vera Golimbet,Stephanie Godard,Hannelore Ehrenreich,Annette M. Hartmann,Frans Henskens,Masashi Ikeda,Nakao Iwata,Assen Jablensky,Inge Joa,Erik G. Jönsson,Brian Kelly,Jo Knight,Bettina Konte,Claudine Laurent-Levinson,James Lee,Todd Lencz,Bernard Lerer,Carmel M. Loughland,Anil K. Malhotra,Jacques Mallet,Colm McDonald,Marina Mitjans,Bryan J. Mowry,Kieran C. Murphy,Robin M. Murray,F. Anthony O'Neill,Sang-Yun Oh,Aarno Palotie,Christos Pantelis,Ann E. Pulver,Tracey L. Petryshen,Digby Quested,Brien P. Riley,Alan R. Sanders,Ulrich Schall,Sibylle G. Schwab,Rodney J. Scott,Pak C. Sham,Jeremy M. Silverman,Kang Sim,Agnes A. Steixner,Paul A. Tooney,Jim van Os,Marquis P. Vawter,Dermot Walsh,Mark Weiser,Dieter B. Wildenauer,Nigel Williams,Brandon Wormley,Fuquan Zhang,Christos Androutsos,Paul D. Arnold,Cathy L. Barr,Csaba Barta,Katharina Bey,O. Joseph Bienvenu,Donald W. Black,Lawrence W. Brown,Cathy L. Budman,Danielle C. Cath,Keun-Ah Cheon,Valentina Ciullo,Barbara J. Coffey,Daniele Cusi,Lea K. Davis,Damiaan Denys,Christel Depienne,Andrea Dietrich,Valsamma Eapen,Peter Falkai,Thomas V. Fernandez,Blanca Garcia-Delgar,Daniel A. Geller,Donald L. Gilbert,Marco A. Grados,Erica Greenberg,Edna Grünblatt,Julie Hagstrøm,Gregory L. Hanna,Andreas Hartmann,Tammy Hedderly,Gary A. Heiman,Isobel Heyman,Hyun Ju Hong,Alden Y. Huang,Chaim Huyser,Laura Ibanez-Gomez,Ekaterina A. Khramtsova,Young Key Kim,Young Shin Kim,Robert A. King,Yun-Joo Koh,Anastasios Konstantinidis,Sodahm Kook,Samuel Kuperman,Bennett L. Leventhal,Christine Lochner,Andrea G. Ludolph,Marcos Madruga-Garrido,Irene A. Malaty,Athanasios Maras,James T. McCracken,Inge A. Meijer,Pablo Mir,Astrid Morer,Kirsten R. Müller-Vahl,Alexander Münchau,Tara Murphy,Allan L. Naarden,Peter Nagy,Gerald Nestadt,Paul S. Nestadt,Humberto Nicolini,Erika L. Nurmi,Michael S. Okun,Peristera Paschou,Fabrizio Piras,Federica Piras,Christopher Pittenger,Kerstin J. Plessen,Margaret A. Richter,Renata Rizzo,Mary M. Robertson,Veit Roessner,Stephan Ruhrmann,Jack Samuels,Paul Sandor,Monika Schlögelhofer,Eun-Young Shin,Harvey S. Singer,Dong-Ho Song,Jungeun Song,Gianfranco Spalletta,Dan J. Stein,S. Evelyn Stewart,Eric A. Storch,Barbara E. Stranger,Manfred Stuhrmann,Zsanett Tarnok,Jay A. Tischfield,Jennifer Tübing,Frank Visscher,Nienke Vulink,Michael Wagner,Susanne Walitza,Sina Wanderer,Martin Woods,Yulia Worbe,Gwyneth Zai,Samuel H. Zinner,Patrick F. Sullivan,Barbara Franke,Mark J. Daly,Cynthia M. Bulik,Andrew M. McIntosh,Michael Conlon O'Donovan,Amanda B Zheutlin,Ole A. Andreassen,Anders D. Børglum,Gerome Breen,Howard J. Edenberg,Ayman H. Fanous,Stephen V. Faraone,Joel Gelernter,Carol A. Mathews,Manuel Mattheisen,Karen S. Mitchell,Michael C. Neale,John I. Nurnberger,Stephan Ripke,Susan L. Santangelo,Jeremiah M. Scharf,Murray B. Stein,Laura M. Thornton,James T.R. Walters,Naomi R. Wray,Naomi R. Wray,Daniel H. Geschwind,Benjamin M. Neale,Kenneth S. Kendler,Jordan W. Smoller +606 more
TL;DR: Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes.
Journal ArticleDOI
Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis
Paul D. Arnold,Kathleen D. Askland,Cristina Barlassina,Laura Bellodi,Oscar J. Bienvenu,Donald W. Black,Michael H. Bloch,Helena Brentani,Christie L. Burton,Beatriz Camarena,Carolina Cappi,Danielle C. Cath,Maria Cristina Cavallini,David V. Conti,Edwin H. Cook,Vladimir Coric,Bernadette Cullen,Danielle Cusi,Lea K. Davis,Richard Delorme,Damiaan Denys,Eske M. Derks,Valsamma Eapen,Christopher K. Edlund,Lauren Erdman,Peter Falkai,Martijn Figee,Abigail J. Fyer,Daniel A. Geller,Fernando S. Goes,Hans J. Grabe,M. A. Grados,Benjamin D. Greenberg,Edna Grünblatt,Wei Guo,Gregory L. Hanna,Sian M. J. Hemmings,Ana Gabriela Hounie,Michael Jenicke,Clare L. Keenan,James L. Kennedy,Ekaterina A. Khramtsova,Anuar Konkashbaev,James A. Knowles,Janice Krasnow,Cristophe Lange,Nuria Lanzagorta,Marion Leboyer,Leonhard Lennertz,Bingbin Li,K. Y. Liang,Christine Lochner,Fabio Macciardi,Brion S. Maher,Wolfgang Maier,Maurizio Marconi,Carol A. Mathews,Manuel Matthesien,James T. McCracken,Nicole C.R. McLaughlin,Euripedes Constantino Miguel,Rainald Moessner,Dennis L. Murphy,Benjamin M. Neale,Gerald Nestadt,Paul S. Nestadt,Humberto Nicolini,Ericka Nurmi,Lisa Osiecki,David L. Pauls,John Piacentini,Danielle Posthuma,Ann E. Pulver,H. D. Qin,Steven A. Rasmussen,Scott L. Rauch,Margaret A. Richter,Mark A. Riddle,Stephan Ripke,Stephan Ruhrmann,Aline S. Sampaio,Jack Samuels,Jeremiah M. Scharf,Yin Yao Shugart,Jan Smit,Dan J. Stein,S. Evelyn Stewart,Maurizio Turiel,Homero Vallada,Jeremy Veenstra-VanderWeele,Michael Wagner,Susanne Walitza,Yi Wang,Jens R. Wendland,Nienke Vulink,Dongmei Yu,Gwyneth Zai +96 more
TL;DR: A meta-analysis from two independent OCD consortia, investigating a total of 2688 individuals of European ancestry with OCD and 7037 genomically matched controls, concludes that the largest single OCD genome-wide study to date represents a major integrative step in elucidating the genetic causes of OCD.
Journal ArticleDOI
TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis.
Liping Su,Liping Su,Sam C. Nalle,Le Shen,Emily S. Turner,Gurminder Singh,Lydia A. Breskin,Ekaterina A. Khramtsova,Galina Khramtsova,Pei-Yun Tsai,Yang Xin Fu,Clara Abraham,Jerrold R. Turner +12 more
TL;DR: In immune-mediated inflammatory bowel disease models, TNFR2 signaling increases long MLCK expression, resulting in tight junction dysregulation, barrier loss, and induction of colitis, which indicates that disease progresses via apoptosis in the absence of M LCK-dependent tight junction regulation.
Journal ArticleDOI
The impact of sex on gene expression across human tissues
Meritxell Oliva,Manuel Muñoz-Aguirre,Sarah Kim-Hellmuth,Sarah Kim-Hellmuth,Valentin Wucher,Ariel D. H. Gewirtz,Daniel J. Cotter,Princy Parsana,Silva Kasela,Brunilda Balliu,Ana Viñuela,Stephane E. Castel,Pejman Mohammadi,François Aguet,Yuxin Zou,Ekaterina A. Khramtsova,Ekaterina A. Khramtsova,Andrew D. Skol,Diego Garrido-Martín,Ferran Reverter,Andrew A. Brown,Patrick Evans,Eric R. Gamazon,Eric R. Gamazon,Anthony Payne,Rodrigo Bonazzola,Alvaro N. Barbeira,Andrew R Hamel,Andrew R Hamel,Angel Martinez-Perez,José Manuel Soria,Brandon L. Pierce,Matthew Stephens,Eleazar Eskin,Emmanouil T. Dermitzakis,Ayellet V. Segrè,Ayellet V. Segrè,Hae Kyung Im,Barbara E. Engelhardt,Kristin G. Ardlie,Stephen B. Montgomery,Alexis Battle,Tuuli Lappalainen,Roderic Guigó,Barbara E. Stranger +44 more
TL;DR: A catalog of sex differences in gene expression and its genetic regulation across 44 human tissue sources surveyed by the GTEx project (v8 data release), analyzing 16,245 RNA-sequencing samples and genotypes of 838 adult individuals is generated.
Journal ArticleDOI
The role of sex in the genomics of human complex traits
TL;DR: Recent insights into the genetic models and mechanisms that lead to sex differences in complex traits are discussed, including genomic evidence for sex-dependent genetic architecture, models and molecular mechanisms of sexually differentiated phenotypes and implications for health care.