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Ekkehard Schütz
Researcher at University of Göttingen
Publications - 201
Citations - 7116
Ekkehard Schütz is an academic researcher from University of Göttingen. The author has contributed to research in topics: Transplantation & Mycophenolic acid. The author has an hindex of 43, co-authored 192 publications receiving 6414 citations. Previous affiliations of Ekkehard Schütz include Sofia Medical University.
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Journal ArticleDOI
The Pharmacokinetic-Pharmacodynamic Relationship for Total and Free Mycophenolic Acid in Pediatric Renal Transplant Recipients: A Report of the German Study Group on Mycophenolate Mofetil Therapy
Lutz T. Weber,Maria Shipkova,Victor W. Armstrong,Natalie Wagner,Ekkehard Schütz,Otto Mehls,Lothar Bernd Zimmerhackl,Michael Oellerich,Burkhard Tönshoff +8 more
TL;DR: Investigation of the pharmacokinetic (PK)/pharmacodynamic relationship of total and free MPA and PK values for the assessment of an individual's MPA PK parameters indicates that therapeutic drug monitoring of MPA has the potential for optimization of MMF efficacy in this patient population by steering patients away from the low values of M PA PK variables that are associated with an increased rejection risk.
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Digital Droplet PCR for Rapid Quantification of Donor DNA in the Circulation of Transplant Recipients as a Potential Universal Biomarker of Graft Injury
Julia Beck,Sarah Bierau,Stefan Balzer,Reiner Andag,Philipp Kanzow,Jessica Schmitz,Jochen Gaedcke,Onnen Moerer,Jan E. Slotta,Philip D. Walson,Otto Kollmar,Michael Oellerich,Ekkehard Schütz +12 more
TL;DR: A novel, cost-effective, rapid technique was developed to quantify GcfDNA in transplant recipients and embodies a promising, potentially universal biomarker for early detection of rejection, which could enable more effective therapeutic interventions.
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Lake Louise Consensus Conference on cyclosporin monitoring in organ transplantation: report of the consensus panel.
Michael Oellerich,Victor W. Armstrong,Barry D. Kahan,Leslie M. Shaw,David W. Holt,Randall W. Yatscoff,A. Lindholm,Philip F. Halloran,K. Gallicano,Kurt Wonigeit,Ekkehard Schütz,Horst Schran,Thomas M. Annesley +12 more
Journal ArticleDOI
Pharmacokinetics of mycophenolic acid (MPA) and determinants of MPA free fraction in pediatric and adult renal transplant recipients. German Study group on Mycophenolate Mofetil Therapy in Pediatric Renal Transplant Recipients.
Lutz T. Weber,Maria Shipkova,T Lamersdorf,Paul Dieter Niedmann,Manfred Wiesel,A. Mandelbaum,Lothar Bernd Zimmerhackl,Ekkehard Schütz,Otto Mehls,Michael Oellerich,Victor W. Armstrong,Burkhard Tönshoff +11 more
TL;DR: Comparing the pharmacokinetics of MPA and its major metabolite MPA glucuronide in pediatric renal transplant recipients receiving 600 mg MMF/m2 body surface area twice a day to those of adults on the currently recommended oral dose of 1 g of MMF once a day is compared.
Journal ArticleDOI
Identification of glucoside and carboxyl-linked glucuronide conjugates of mycophenolic acid in plasma of transplant recipients treated with mycophenolate mofetil
Maria Shipkova,Victor W. Armstrong,Eberhard Wieland,Paul Dieter Niedmann,Ekkehard Schütz,Gerald Brenner-Weiß,Martin Voihsel,Felix Braun,Michael Oellerich +8 more
TL;DR: Results suggest that M‐1 is the 7‐OH glucose conjugate of MPA; M‐2 is the acyl glucuronide conjugates of M PA; and M‐3 is derived from the hepatic CYP450 system.