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El-ad David Amir
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 32
Citations - 8985
El-ad David Amir is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Immune system & Mass cytometry. The author has an hindex of 18, co-authored 29 publications receiving 6931 citations. Previous affiliations of El-ad David Amir include Columbia University & Ben-Gurion University of the Negev.
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Journal ArticleDOI
Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum
Sean C. Bendall,Erin F. Simonds,Peng Qiu,El-ad David Amir,Peter O. Krutzik,Rachel Finck,Robert V. Bruggner,Rachel D. Melamed,Angelica Trejo,Olga Ornatsky,Robert S. Balderas,Sylvia K. Plevritis,Karen Sachs,Dana Pe'er,Scott D. Tanner,Garry P. Nolan +15 more
TL;DR: Single-cell “mass cytometry” analyses provide system-wide views of immune signaling in healthy human hematopoiesis, against which drug action and disease can be compared for mechanistic studies and pharmacologic intervention.
Journal ArticleDOI
Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis.
Jacob H. Levine,Erin F. Simonds,Sean C. Bendall,Kara L. Davis,El-ad David Amir,Michelle D. Tadmor,Oren Litvin,Harris G. Fienberg,Astraea Jager,Eli R. Zunder,Rachel Finck,Amanda Larson Gedman,Ina Radtke,James R. Downing,Dana Pe'er,Garry P. Nolan +15 more
TL;DR: Using hematopoietic progenitors, a signaling-based measure of cellular phenotype was defined, which led to isolation of a gene expression signature that was predictive of survival in independent cohorts, yielding insights into AML pathophysiology.
Journal ArticleDOI
viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia
El-ad David Amir,Kara L. Davis,Michelle D. Tadmor,Erin F. Simonds,Jacob H. Levine,Sean C. Bendall,Daniel K. Shenfeld,Smita Krishnaswamy,Garry P. Nolan,Dana Pe'er +9 more
TL;DR: In this article, the authors present viSNE, a tool that allows one to map high-dimensional cytometry data onto two dimensions, yet conserve the highdimensional structure of the data by using all pairwise distances in high dimension to determine each cell's location in the plot.
Journal ArticleDOI
Single-Cell Trajectory Detection Uncovers Progression and Regulatory Coordination in Human B Cell Development
Sean C. Bendall,Kara L. Davis,El-ad David Amir,Michelle D. Tadmor,Erin F. Simonds,Tiffany J. Chen,Daniel K. Shenfeld,Garry P. Nolan,Dana Pe'er +8 more
TL;DR: This study provides a comprehensive analysis of human B lymphopoiesis, laying a foundation to apply this approach to other tissues and "corrupted" developmental processes including cancer.
Journal ArticleDOI
Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses.
Yonit Lavin,Soma Kobayashi,Andrew Leader,El-ad David Amir,Naama Elefant,Camille Bigenwald,Romain Remark,Robert Sweeney,Christian Becker,Jacob H. Levine,Klaus Meinhof,Andrew Chow,Seunghee Kim-Shulze,Andrea S. Wolf,Chiara Medaglia,Hanjie Li,Julie A. Rytlewski,Ryan O. Emerson,Alexander Solovyov,Benjamin Greenbaum,Catherine Sanders,Marissa Vignali,Mary Beth Beasley,Raja M. Flores,Sacha Gnjatic,Dana Pe'er,Adeeb Rahman,Ido Amit,Miriam Merad +28 more
TL;DR: It is shown that stage I lung adenocarcinoma lesions already harbor significantly altered T cell and NK cell compartments, andaired single-cell analyses thus offer valuable knowledge of tumor-driven immune changes, providing a powerful tool for the rational design of immune therapies.