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El-Shaimaa A. Arafa
Researcher at Ajman University of Science and Technology
Publications - 59
Citations - 1712
El-Shaimaa A. Arafa is an academic researcher from Ajman University of Science and Technology. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 21, co-authored 46 publications receiving 1279 citations. Previous affiliations of El-Shaimaa A. Arafa include Beni-Suef University & Ohio State University.
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Journal ArticleDOI
Diosmin protects against ethanol-induced gastric injury in rats: novel anti-ulcer actions.
TL;DR: Findings accentuate the gastroprotective actions of DIO in ethanol gastric injury which were mediated via concerted multi-pronged actions, including suppression of gastric inflammation, oxidative stress and apoptosis besides boosting of the antioxidant and the cytoprotective defenses.
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Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells.
El-Shaimaa A. Arafa,Qianzheng Zhu,Zubair Shah,Gulzar Wani,Bassant M. Barakat,Ira Racoma,Mohamed A. El-Mahdy,Altaf A. Wani +7 more
TL;DR: The results reveal that up-regulation of the key upstream signaling factor, PTEN, in MCF-7/DOX cells inhibited Akt phosphorylation, which ultimately causes increase in their regulatory p53 levels affecting the induction of G2/M cell cycle arrest and apoptosis.
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Tangeretin sensitizes cisplatin-resistant human ovarian cancer cells through downregulation of phosphoinositide 3-kinase/Akt signaling pathway.
El-Shaimaa A. Arafa,Qianzheng Zhu,Bassant M. Barakat,Gulzar Wani,Qun Zhao,Mohamed A. El-Mahdy,Altaf A. Wani +6 more
TL;DR: The overall results indicated that tangeretin exposure preconditions cisplatin-resistant human ovarian cancer cells for a conventional response to low-dose cisPlatin-induced cell death occurring through downregulation of PI3K/Akt signaling pathway.
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Tangeretin Alleviates Cisplatin-Induced Acute Hepatic Injury in Rats: Targeting MAPKs and Apoptosis.
Hany A. Omar,Hany A. Omar,Wafaa R. Mohamed,Hany H. Arab,El-Shaimaa A. Arafa,El-Shaimaa A. Arafa +5 more
TL;DR: The results highlight the protective effects of tangeretin against cisplatin-induced acute hepatic injury via the concerted modulation of inflammation, oxidative stress, MAPKs and apoptotic pathways.
Journal ArticleDOI
Camel's milk ameliorates TNBS-induced colitis in rats via downregulation of inflammatory cytokines and oxidative stress.
Hany H. Arab,Hany H. Arab,Samir A. Salama,Ahmed H. Eid,Hany A. Omar,El-Shaimaa A. Arafa,Ibrahim A. Maghrabi +6 more
TL;DR: CM effectively suppressed the severity of colon injury as evidenced by amelioration of macroscopic damage, colon weight/length ratio, histopathological alterations, leukocyte influx and myeloperoxidase activity and may be an interesting complementary approach for the management of IBD.