E
Elaine Kwan
Researcher at University of California, Berkeley
Publications - 5
Citations - 1960
Elaine Kwan is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Gene & Drosophila embryogenesis. The author has an hindex of 5, co-authored 5 publications receiving 1866 citations. Previous affiliations of Elaine Kwan include Howard Hughes Medical Institute.
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Journal ArticleDOI
Systematic determination of patterns of gene expression during Drosophila embryogenesis
Pavel Tomancak,Amy Beaton,Richard Weiszmann,Elaine Kwan,ShengQiang Shu,Suzanna E. Lewis,Stephen Richards,Michael Ashburner,Volker Hartenstein,Susan E. Celniker,Gerald M. Rubin,Gerald M. Rubin +11 more
TL;DR: Analyzing gene-expression patterns by in situ hybridization to whole-mount embryos provides an extremely rich dataset that can be used to identify genes involved in developmental processes that have been missed by traditional genetic analysis.
Journal ArticleDOI
Drosophila p53 Binds a Damage Response Element at the reaper Locus
Michael H. Brodsky,William Nordstrom,Garson Tsang,Elaine Kwan,Gerald M. Rubin,John M. Abrams +5 more
TL;DR: Results indicate that reaper is a direct transcriptional target of Drosophila p53 following DNA damage, and a multimer of this site is sufficient for radiation induction in vivo.
Journal ArticleDOI
Global analysis of patterns of gene expression during Drosophila embryogenesis.
Pavel Tomancak,Pavel Tomancak,Pavel Tomancak,Benjamin P. Berman,Benjamin P. Berman,Amy Beaton,Amy Beaton,Richard Weiszmann,Elaine Kwan,Elaine Kwan,Volker Hartenstein,Susan E. Celniker,Gerald M. Rubin,Gerald M. Rubin,Gerald M. Rubin +14 more
TL;DR: Nearly 60% of the genes with detectable expression exhibit broad patterns reflecting quantitative rather than qualitative differences between tissues, and the expression patterns of over 1,500 of these genes are documented here for the first time.
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PHYL Acts to Down-Regulate TTK88, a Transcriptional Repressor of Neuronal Cell Fates, by a SINA-Dependent Mechanism
TL;DR: The results suggest a model in which activation of the Sevenless receptor tyrosine kinase induces PHYL expression, which then acts with SINA to target the transcriptional repressor TTK88 for degradation, thereby promoting R7 cell fate specification.
Journal ArticleDOI
Functional analysis of CNK in RAS signaling
TL;DR: It is shown that the N-terminal portion of CNK (CNK(N-term)) strongly cooperates with RAS, whereas CNK(C-term) efficiently blocks RAS- and RAF-dependent signaling when overexpressed in the Drosophila eye, suggesting that CNK functions in more than one pathway downstream of RAS.