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Elena Shklovskaya
Researcher at Macquarie University
Publications - 36
Citations - 1402
Elena Shklovskaya is an academic researcher from Macquarie University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 17, co-authored 31 publications receiving 1094 citations. Previous affiliations of Elena Shklovskaya include Russian Academy & University of Sydney.
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Journal ArticleDOI
Cutaneous immunosurveillance by self-renewing dermal γδ T cells
Nital Sumaria,Ben Roediger,Lai Guan Ng,Jim S. Qin,Rachel Pinto,Lois L. Cavanagh,Elena Shklovskaya,Barbara Fazekas de St Groth,Barbara Fazekas de St Groth,James A. Triccas,Wolfgang Weninger,Wolfgang Weninger,Wolfgang Weninger +12 more
TL;DR: In this article, the authors describe a prominent population of resident dermal γδ T cells, which differ from DETCs in TCR usage, phenotype, and migratory behavior.
Journal ArticleDOI
Langerhans cells are precommitted to immune tolerance induction
Elena Shklovskaya,Brendan O'Sullivan,Lai Guan Ng,Lai Guan Ng,Lai Guan Ng,Ben Roediger,Ranjeny Thomas,Wolfgang Weninger,Wolfgang Weninger,Barbara Fazekas de St Groth,Barbara Fazekas de St Groth +10 more
TL;DR: In this article, the authors tested whether epidermal Langerhans cells (LCs) can support immunogenic responses in vivo in the absence of antigen presentation by other dendritic cells (DCs).
Journal ArticleDOI
Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition.
Jenny H. Lee,Elena Shklovskaya,Su Yin Lim,Matteo S. Carlino,Alexander M. Menzies,Ashleigh Stewart,Bernadette Pedersen,Malama Irvine,Sara Alavi,Jean Yee Hwa Yang,Dario Strbenac,Robyn P. M. Saw,Robyn P. M. Saw,John F. Thompson,John F. Thompson,James S. Wilmott,Richard A. Scolyer,Richard A. Scolyer,Georgina V. Long,Richard F. Kefford,Helen Rizos +20 more
TL;DR: It is shown that resistance to anti-PD-1 blockade is associated with TGF-beta driven major histocompatibility complex I (MHCI) down-regulation and a de-differentiated phenotype in melanoma patients.
Journal ArticleDOI
IL-2 is a critical regulator of group 2 innate lymphoid cell function during pulmonary inflammation.
Ben Roediger,Ben Roediger,Ryan Kyle,Szun S. Tay,Szun S. Tay,Andrew J. Mitchell,Andrew J. Mitchell,Holly A. Bolton,Holly A. Bolton,Thomas V. Guy,Thomas V. Guy,Sioh Yang Tan,Sioh Yang Tan,Elizabeth Forbes-Blom,Philip L. Tong,Philip L. Tong,Philip L. Tong,Yasmin Köller,Elena Shklovskaya,Elena Shklovskaya,Makio Iwashima,Kathy D. McCoy,Graham Le Gros,Graham Le Gros,Barbara Fazekas de St Groth,Barbara Fazekas de St Groth,Wolfgang Weninger,Wolfgang Weninger,Wolfgang Weninger +28 more
TL;DR: In this paper, the role of IL-2 in the regulation of group 2 innate lymphoid cells (ILC2) function in the lung has been investigated and shown to serve two distinct functions, namely promoting cell survival/proliferation and serving as a cofactor for the production of type 2 cytokines.
Journal ArticleDOI
Epidermal and Dermal Dendritic Cells Display Differential Activation and Migratory Behavior While Sharing the Ability to Stimulate CD4+ T Cell Proliferation In Vivo
TL;DR: In this article, the authors used BM chimeric mice that differ in CD45 and MHC class II alleles to unequivocally distinguish between radioresistant m-LCs and radiosensitive migrated dermal cells (m-dDCs), to determine their phenotype, response to contact sensitization, and ability to activate naive CD4+ T cells in vivo.