Author
Elia Tfouni
Other affiliations: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto
Bio: Elia Tfouni is an academic researcher from University of São Paulo. The author has contributed to research in topics: Ruthenium & Aquation. The author has an hindex of 15, co-authored 26 publications receiving 905 citations. Previous affiliations of Elia Tfouni include Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto.
Topics: Ruthenium, Aquation, Cyclam, Sodium nitroprusside, Singlet state
Papers
More filters
TL;DR: In this article, the site of the reduction [Ru(NO)]3++e−→[Ru( NO)]2+ was assigned to the NO ligand based on molecular orbital (MO) analysis and on reduction product analysis.
275 citations
TL;DR: The chemical and photochemical properties of several ruthenium amine complexes as NO-carriers in vitro and in vivo have been reviewed and these nitrosyl complexes can stimulate mice hippocampus slices, promote the lowering of blood pressure in several in vivo models, and control Trypanosoma cruzi and Leishmania major infections.
149 citations
TL;DR: This tailoring approach is explored here, being heavily supported by the accumulated knowledge on the chemistry and photochemistry of ruthenium complexes, which allows NO donors/scavengers systems to be custom made designed.
Abstract: The discovery of the involvement of nitric oxide (NO) in several physiological and pathophysiological processes launched a spectacular increase in studies in areas such as chemistry, biochemistry, and pharmacology. As a consequence, the development of NO donors or scavengers for regulation of its concentration and bioavailability in vivo is required. In this sense, ruthenium nitrosyl ammines and aliphatic tetraazamacrocyles have attracted a lot of attention due to their unique chemical properties. These complexes are water soluble and stable in solution, not to mention that they can deliver NO when photochemically or chemically activated by the reduction of the coordinated nitrosonium (NO+). The tuning of the energies of the charge transfer bands, the redox potential, and the specific rate constants of NO liberation, in both solution and matrices, is desirable for the achievement of selective NO delivery to biological targets, hence making the ruthenium ammines and aliphatic tetraazamacrocyles a quite versatile platform for biological application purposes. These ruthenium nitrosyls have shown to be active in firing neurons in mouse hippocampus, performing redox reactions in mitochondria, acting in blood pressure control, exhibiting cytotoxic activities against trypanosomatids (T.cruzi and L.major) and tumor cells. This tailoring approach is explored here, being heavily supported by the accumulated knowledge on the chemistry and photochemistry of ruthenium complexes, which allows NO donors/scavengers systems to be custom made designed.
65 citations
TL;DR: Cyclam-NO showed an hypotensive effect around 20 times longer than SNP in either normotensive or hypertensive rats, which was completely inhibited by methylene blue or carboxy-PTIO.
61 citations
TL;DR: In this paper, the authors describe methods for the characterization of ruthenium complexes into/onto functionalized silica gel, zeolites, polymers, dendrimers, sol-gel, nano and microparticles.
58 citations
Cited by
More filters
TL;DR: The review covers the knowledge on photoremovable protecting groups and includes all relevant chromophores studied in the time period of 2000–2012 and the most relevant earlier works are discussed.
Abstract: The review covers the knowledge on photoremovable protecting
groups and includes all relevant chromophores studied in the
time period of 2000–2012; the most relevant earlier works are
also discussed.
1,274 citations
TL;DR: In this article, a comparison of these calculations with those carried out using Zerner's frequently used INDO/S method is described and discussed, and it is shown that for these species, and probably for all non-solvatochromic species in general, INDO-S is a good model reproducing very well the results of the computationally much more demanding but also more reliable TD-DFRT calculations.
896 citations
887 citations
TL;DR: Biological carriers conjugated to cisplatin analogs have improved specificity for tumor tissue, thereby reducing side effects and drug resistance, and metal-based chemotherapeutic compounds have the potential to modulate the biological properties of superoxide anion and nitric oxide.
853 citations
657 citations