Eliana Aparecida Varanda

TL;DR: It is necessary to clarify the conditions and the mechanisms that mediate the biological effects of flavonoids before treating them as therapeutical agents, since some compounds can be biotransformed into more genotoxic products; as is the case for galangin, kaempferol and quercetin.

TL;DR: Assessment of the qualitative and quantitative profiles of the ethanolic extract from the stem bark of C. ferrea and the absence of any mutagenic effect in the Salmonella/microsome assay is important for pharmacological purposes and the safe use of this plant.

TL;DR: The extract was shown to induce frameshift, base pair substitution and damage to the chromosomes, however, this effect was less deleterious than the clastogenic effect of ciclophosphamide.

TL;DR: The genotoxic potential of crude extracts and fractions containing alkaloids and flavonoids from the leaves of this plant, on Salmonella typhimurium and the micronucleus test on peripheral blood cells of mice treated in vivo showed that the methanol extract of the Leaves of S. pseudoquina is mutagenic to the TA98 (-S9) and TA100 (+S9, -S9).

TL;DR: The antimutagenic effect of ethanolic extract of propolis (EEP) and honeybee venom, both collected in the State of São Paulo, Brazil, was assessed by the Salmonella/microsome assay upon direct- and indirect-acting mutagens.