Elisa Benetti

TL;DR: The GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2244 critically ill Covid-19 patients from 208 UK intensive care units is reported, finding evidence in support of a causal link from low expression of IFNAR2, and high expression of TYK2, to life-threatening disease.

TL;DR: Findings suggest that a predisposing genetic background may contribute to the observed interindividual clinical variability associated with COVID-19, allowing an evidence-based risk assessment leading to personalized preventive measures and therapeutic options.

TL;DR: In this paper, a nested case-control study in which compared male participants with extreme phenotype selected from the Italian GEN-COVID cohort of SARS-CoV-2-infected participants was conducted.

TL;DR: Polymorphisms/rare variants in certain genes, including short polyQ of the androgen receptor, conferred protection against severe forms of COVID-19, and testosterone was higher in males with AR long-polyQ, confirming receptor resistance and contributing to designing reliable clinical and public health measures.

TL;DR: Findings suggest that a predisposing genetic background may contribute to the observed inter-individual clinical variability associated with COVID-19, and allow an evidence-based risk assessment opening up the way to personalized preventive measures and therapeutic options.