Elisabeth Hansson

TL;DR: Specific interactions between the brain endothelium, astrocytes and neurons that may regulate blood–brain barrier function are explored to lead to the development of new protective and restorative therapies.

TL;DR: Basic data on glial neuronal signaling is summarized to provide insight into synaptic modulation and reconstruction in physiology and protection and repair of nervous tissue after damage.

TL;DR: Of the stimuli used, only LPS induced a significant release of the proinflammatory cytokines tumor necrosis factor‐α (TNF‐α) and interleukin‐6 (IL‐6), and was the only stimulus that increased microglial GLT‐1 expression and glutamate uptake capacity after 12‐h incubation, indicating TNF‐ α as an inducer of GLT-1 expression in microglia.

TL;DR: Astroglia might exert a neuroprotective function in situations of moderately increased extracellular Glu concentrations, i.e., corresponding to conditions of pathological hyper-excitability, or corresponding to early stages of an acute brain injury.

TL;DR: Heterogeneity among astroglial cells from different brain regions in intercellular calcium signaling and in its differential modulation by neurotransmitters is suggested, probably reflecting functional requirements in various brain regions.