Elisabeth Vogelsang

TL;DR: It is estimated that the 372 genes defined by the mutants probably represent more than half of all genes that could have been discovered using the criteria of the screen, and the limits and the potentials of a genetic saturation screen in the zebrafish.

TL;DR: It is demonstrated that it is feasible to screen for genes specific for the patterning or function of certain internal organs in the zebrafish and the mutations presented here could serve as an entry point to the establishment of a genetic hierarchy underlying organogenesis.

TL;DR: The collection of mutants presented here represent several steps required for normal erythropoiesis, and provides a powerful approach towards defining the molecular mechanisms involved in vertebrate hematopoietic development.

TL;DR: It is proposed that the polarizing activity, normally present at the ventral side of the egg, is a ligand for the Toll receptor, and local activation of the Toll protein by the ligand initiates the formation of the nuclear concentration gradient of the dorsal protein, thereby determining dorsoventral pattern.

TL;DR: In a large scale screen for mutants with defects in the embryonic development of the zebrafish, mutations in four genes,floating head (flh), momo (mom), no tail (ntl), and doc, that are required for early notochord formation are identified.