E
Elizabeth P. Murchison
Researcher at University of Cambridge
Publications - 69
Citations - 12535
Elizabeth P. Murchison is an academic researcher from University of Cambridge. The author has contributed to research in topics: Devil facial tumour disease & Dicer. The author has an hindex of 36, co-authored 62 publications receiving 11569 citations. Previous affiliations of Elizabeth P. Murchison include Columbia University & Watson School of Biological Sciences.
Papers
More filters
Journal ArticleDOI
Dicer is essential for mouse development.
Emily Bernstein,Sang Yong Kim,Michelle A. Carmell,Michelle A. Carmell,Elizabeth P. Murchison,Heather L. Alcorn,Mamie Z. Li,Alea A. Mills,Stephen J. Elledge,Kathryn V. Anderson,Gregory J. Hannon +10 more
TL;DR: A role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development is suggested.
Journal ArticleDOI
A MicroRNA Feedback Circuit in Midbrain Dopamine Neurons
Jongpil Kim,Keiichi Inoue,Keiichi Inoue,Jennifer Ishii,Jennifer Ishii,William B. Vanti,William B. Vanti,Sergey V. Voronov,Sergey V. Voronov,Elizabeth P. Murchison,Elizabeth P. Murchison,Gregory J. Hannon,Gregory J. Hannon,Asa Abeliovich,Asa Abeliovich +14 more
TL;DR: AmiR-133b regulates the maturation and function of midbrain DNs within a negative feedback circuit that includes the paired-like homeodomain transcription factor Pitx3, and a role for this feedback circuit in the fine-tuning of dopaminergic behaviors such as locomotion is proposed.
Journal ArticleDOI
Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes
Oliver H. Tam,Alexei A. Aravin,Paula Stein,Angélique Girard,Elizabeth P. Murchison,Sihem Cheloufi,Emily Hodges,Martin Anger,Martin Anger,Ravi Sachidanandam,Richard M. Schultz,Gregory J. Hannon +11 more
TL;DR: These findings indicate a function for pseudogenes in regulating gene expression by means of the RNA interference pathway and may, in part, explain the evolutionary pressure to conserve argonaute-mediated catalysis in mammals.
Journal ArticleDOI
Characterization of Dicer-deficient murine embryonic stem cells
TL;DR: In this paper, a conditional model of RNAi deficiency in mammals was presented, where the absence of Dicer does not affect the ability of small interfering RNAs to repress gene expression.
Journal ArticleDOI
Genome analysis of the platypus reveals unique signatures of evolution
Wesley C. Warren,LaDeana W. Hillier,Jennifer A. Marshall Graves,Ewan Birney,Chris P. Ponting,Frank Grützner,Katherine Belov,Webb Miller,Laura Clarke,Asif T. Chinwalla,Shiaw Pyng Yang,Andreas Heger,Devin P. Locke,Pat Miethke,Paul D. Waters,Frédéric Veyrunes,Frédéric Veyrunes,Lucinda Fulton,Bob Fulton,Tina Graves,John W. Wallis,Xose S. Puente,Carlos López-Otín,Gonzalo R. Ordóñez,Evan E. Eichler,Lin Chen,Ze Cheng,Janine E. Deakin,Amber E. Alsop,Katherine Thompson,Patrick J. Kirby,Anthony T. Papenfuss,Matthew Wakefield,Tsviya Olender,Doron Lancet,Gavin A. Huttley,Arian F.A. Smit,Andrew J Pask,Peter Temple-Smith,Peter Temple-Smith,Mark A. Batzer,Jerilyn A. Walker,Miriam K. Konkel,Robert S. Harris,Camilla M. Whittington,Emily S. W. Wong,Neil J. Gemmell,Emmanuel Buschiazzo,Iris M. Vargas Jentzsch,Angelika Merkel,Juergen Schmitz,Anja Zemann,Gennady Churakov,Jan Ole Kriegs,Juergen Brosius,Elizabeth P. Murchison,Ravi Sachidanandam,Carly Smith,Gregory J. Hannon,Enkhjargal Tsend-Ayush,Daniel McMillan,Rosalind Attenborough,Willem Rens,Malcolm A. Ferguson-Smith,Christophe Lefevre,Christophe Lefevre,Julie A. Sharp,Kevin R. Nicholas,David A. Ray,Michael Kube,Richard Reinhardt,Thomas H. Pringle,James Taylor,Russell C. Jones,Brett Nixon,Jean Louis Dacheux,Hitoshi Niwa,Yoko Sekita,Xiaoqiu Huang,Alexander Stark,Pouya Kheradpour,Manolis Kellis,Paul Flicek,Yuan Chen,Caleb Webber,Ross C. Hardison,Joanne O. Nelson,Kym Hallsworth-Pepin,Kim D. Delehaunty,Chris Markovic,Patrick Minx,Yucheng Feng,Colin Kremitzki,Makedonka Mitreva,Jarret Glasscock,Todd Wylie,Patricia Wohldmann,Prathapan Thiru,Michael N. Nhan,Craig Pohl,Scott M. Smith,Shunfeng Hou,Marilyn B. Renfree,Elaine R. Mardis,Richard K. Wilson +104 more
TL;DR: It is found that reptile and platypus venom proteins have been co-opted independently from the same gene families; milk protein genes are conserved despite platypuses laying eggs; and immune gene family expansions are directly related to platypUS biology.