E
Elke S. Bergmann-Leitner
Researcher at Walter Reed Army Institute of Research
Publications - 106
Citations - 6232
Elke S. Bergmann-Leitner is an academic researcher from Walter Reed Army Institute of Research. The author has contributed to research in topics: Antigen & Malaria vaccine. The author has an hindex of 35, co-authored 91 publications receiving 5460 citations. Previous affiliations of Elke S. Bergmann-Leitner include United States Department of the Army & National Institutes of Health.
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Journal ArticleDOI
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis.
Stephan Frank,Brigitte Gaume,Elke S. Bergmann-Leitner,Wolfgang W. Leitner,Everett G. Robert,Frédéric Catez,Carolyn L. Smith,Richard J. Youle +7 more
TL;DR: In healthy cells, fusion and fission events participate in regulating mitochondrial morphology and inhibition of Drp1 blocks cell death, implicating mitochondrial fission as an important step in apoptosis.
Journal ArticleDOI
Anti-cancer drugs
TL;DR: The anti-cancer agents are classified according to chemical structure and resource of the drug such as Alkylating Agents, Antimetabolite, Antibiotics, Plant Extracts, hormones, Others.
Journal ArticleDOI
Phase 1/2a Study of the Malaria Vaccine Candidate Apical Membrane Antigen-1 (AMA-1) Administered in Adjuvant System AS01B or AS02A
Michele D. Spring,James F. Cummings,Christian F. Ockenhouse,Sheetij Dutta,Randall Reidler,Evelina Angov,Elke S. Bergmann-Leitner,V. Ann Stewart,Stacey Bittner,Laure Y. Juompan,Mark G. Kortepeter,Robin Nielsen,Urszula Krzych,Ev Tierney,Lisa A. Ware,Megan Dowler,Cornelus C. Hermsen,Robert W. Sauerwein,Sake J. de Vlas,Opokua Ofori-Anyinam,David E. Lanar,Jack Williams,Kent E. Kester,Kathryn Tucker,Meng Shi,Elissa Malkin,Carole A. Long,Carter L. Diggs,Lorraine Soisson,Marie-Claude Dubois,W. Ripley Ballou,Joe Cohen,D. Gray Heppner +32 more
TL;DR: All three vaccine formulations were found to be safe and highly immunogenic and immune responses did not translate into significant vaccine efficacy in malaria-naïve adults employing a primary sporozoite challenge model, but encouragingly, estimation of parasite growth rates from qPCR data may suggest a partial biological effect of the vaccine.
Journal ArticleDOI
Safety and immunogenicity of an AMA1 malaria vaccine in Malian children: results of a phase 1 randomized controlled trial.
Mahamadou A. Thera,Ogobara K. Doumbo,Drissa Coulibaly,Dapa A. Diallo,Abdoulaye K. Kone,Ando B. Guindo,Karim Traore,Alassane Dicko,Issaka Sagara,Mahamadou S. Sissoko,Mounirou Baby,Mady Sissoko,Issa Diarra,Amadou Niangaly,Amagana Dolo,Modibo Daou,Sory I. Diawara,D. Gray Heppner,V. Ann Stewart,Evelina Angov,Elke S. Bergmann-Leitner,David E. Lanar,Sheetij Dutta,Lorraine Soisson,Carter L. Diggs,Amanda J. Leach,Alex Owusu,Marie-Claude Dubois,Joe Cohen,Jason N. Nixon,Aric L. Gregson,Shannon L. Takala,Kirsten E. Lyke,Christopher V. Plowe +33 more
TL;DR: Anti-AMA-1 antibodies increased significantly in both malaria vaccine groups, peaking at nearly 5-fold and more than 6-fold higher than baseline in the half-dose and full-dose groups, respectively.