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Ellen K. Gagliani
Researcher at University of Cincinnati Academic Health Center
Publications - 5
Citations - 43
Ellen K. Gagliani is an academic researcher from University of Cincinnati Academic Health Center. The author has contributed to research in topics: Notch signaling pathway & Transcription factor. The author has an hindex of 1, co-authored 5 publications receiving 8 citations. Previous affiliations of Ellen K. Gagliani include Cincinnati Children's Hospital Medical Center & University of Cincinnati.
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Book ChapterDOI
Transcription Factor RBPJ as a Molecular Switch in Regulating the Notch Response.
TL;DR: This work focuses on the recent advances concerning RBPJ-corepressor functions, especially in regard to chromatin regulation, and puts this into the context of one of the best-studied model systems for Notch, blood cell development.
Journal ArticleDOI
PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion
Sebastian K.-J. Landor,Niina M. Santio,William B. Eccleshall,William B. Eccleshall,Valeriy M. Paramonov,Valeriy M. Paramonov,Ellen K. Gagliani,Daniel Hall,Shao Bo Jin,Käthe M. Dahlström,Tiina A. Salminen,Adolfo Rivero-Müller,Adolfo Rivero-Müller,Urban Lendahl,Rhett A. Kovall,Päivi J. Koskinen,Cecilia Sahlgren,Cecilia Sahlgren +17 more
TL;DR: In this paper, the Notch3 ICD (N3ICD) was shown to be phosphorylated within a domain, which is essential for formation of a transcriptionally active complex with the DNA-binding protein CSL.
Journal ArticleDOI
Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor
Yi Kuang,Anna Pyo,Natanel Eafergan,Brittany Cain,Lisa M. Gutzwiller,Ofri Axelrod,Ellen K. Gagliani,Matthew T. Weirauch,Matthew T. Weirauch,Raphael Kopan,Raphael Kopan,Rhett A. Kovall,David Sprinzak,Brian Gebelein,Brian Gebelein +14 more
TL;DR: In this paper, the authors show that SPS containing enhancers preferentially recruit cooperative Notch activation complexes over hairless co-repressor complexes to ensure consistent target gene activation.
Posted ContentDOI
Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor
Yi Kuang,Anna Pyo,Natanel Eafergan,Brittany Cain,Lisa M. Gutzwiller,Ofri Axelrod,Ellen K. Gagliani,Matthew T. Weirauch,Raphael Kopan,Rhett A. Kovall,David Sprinzak,Brian Gebelein +11 more
TL;DR: These findings support a model in which SPS containing enhancers preferentially recruit cooperative Notch activation complexes over Hairless repression complexes to ensure consistent target gene activation.
Posted ContentDOI
A Drosophila Su(H) Model of Adams-Oliver Syndrome Reveals Notch Cofactor Titration as a Mechanism Underlying Developmental Defects
Ellen K. Gagliani,Lisa M. Gutzwiller,Yi Kuang,Yoshinobu Odaka,Phillipp Hoffmeister,Stefanie Hauff,Aleksandra Turkiewicz,Emily Harding-Theobald,Patrick J. Dolph,Tilman Borggrefe,Franz Oswald,Brian Gebelein,Rhett A. Kovall +12 more
TL;DR: In this paper, a cofactor sequestration mechanism underlies Adams-Oliver syndrome (AOS), a rare autosomal dominant disorder characterized by scalp, cranium, and limb defects.