E
Ellen R. Goldman
Researcher at United States Naval Research Laboratory
Publications - 183
Citations - 17109
Ellen R. Goldman is an academic researcher from United States Naval Research Laboratory. The author has contributed to research in topics: Single-domain antibody & Förster resonance energy transfer. The author has an hindex of 43, co-authored 177 publications receiving 16170 citations. Previous affiliations of Ellen R. Goldman include Massachusetts Institute of Technology & George Mason University.
Papers
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Journal ArticleDOI
Quantum dot bioconjugates for imaging, labelling and sensing
TL;DR: This review looks at current methods for preparing QD bioconjugates as well as presenting an overview of applications, and concludes that the potential of QDs in biology has just begun to be realized and new avenues will arise as the ability to manipulate these materials improves.
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Self-Assembly of CdSe−ZnS Quantum Dot Bioconjugates Using an Engineered Recombinant Protein
Hedi Mattoussi,J. Matthew Mauro,Ellen R. Goldman,George M. Anderson,Vikram C. Sundar,and Frederic V. Mikulec,Moungi G. Bawendi +6 more
TL;DR: A novel and direct method is described for conjugating protein molecules to luminescent CdSe−ZnS core−shell nanocrystals (Quantum Dots) for use as bioactive fluorescent probes in sensing, imaging, immunoassay, and other diagnostics applications.
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Self-assembled nanoscale biosensors based on quantum dot FRET donors
Igor L. Medintz,Aaron R. Clapp,Hedi Mattoussi,Ellen R. Goldman,Brent Fisher,J. Matthew Mauro,J. Matthew Mauro +6 more
TL;DR: The design, formation and testing of QD–protein assemblies that function as chemical sensors that overcomes inherent QD donor–acceptor distance limitations are reported.
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Multiplexed toxin analysis using four colors of quantum dot fluororeagents.
Ellen R. Goldman,Aaron R. Clapp,George M. Anderson,H. Tetsuo Uyeda,J. Matthew Mauro,Igor L. Medintz,Hedi Mattoussi +6 more
TL;DR: This work prepared bioinorganic conjugates made with highly luminescent semiconductor nanocrystals and antibodies and antibodies to perform multiplexed fluoroimmunoassays and demonstrated the simultaneous detection of the four toxins from a single sample probed with a mixture of all four QD-antibody reagents.
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A Hybrid Quantum Dot−Antibody Fragment Fluorescence Resonance Energy Transfer-Based TNT Sensor
Ellen R. Goldman,Igor L. Medintz,Jessica L. Whitley,Andrew Hayhurst,Aaron R. Clapp,H. Tetsuo Uyeda,Jeffrey R. Deschamps,Michael E. Lassman,Hedi Mattoussi +8 more
TL;DR: The use of luminescent QDs conjugated to antibody fragments to develop solution-phase nanoscale sensing assemblies, based on fluorescence resonance energy transfer (FRET) for the specific detection of the explosive 2,4,6-trinitrotoluene (TNT) in aqueous environments is demonstrated.