Elodie Laine

TL;DR: This paper presented a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over three years, representing the first systematic, worldwide catalog of the urban microbial ecosystem.

TL;DR: CAPRI Round 46 indicates that residues in binding interfaces were less well predicted in this set of targets than in previous Rounds, providing useful insights for directions of future improvements.

TL;DR: A plausible molecular rationale is proposed to propose that JMR is able to depart its auto-inhibitory position more easily in the mutant than in wild-type KIT and is thus able to promote kinase mutant dimerization without the need for extra-cellular ligand binding.

TL;DR: The procedure for identifying the regions of a protein that can be used to control its activity through allostery is described, based on the construction of a plausible conformational path that describes protein transition between known active and inactive conformations.

TL;DR: This detailed characterization of the allosteric communication in the different forms of KIT, native and mutants, was performed by using a modular network representation composed of communication pathways and independent dynamic segments to enrich a purely mechanistic interaction-based model of protein communication by the introduction of concerted local atomic fluctuations.