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Emad S. Elsubeihi

Bio: Emad S. Elsubeihi is an academic researcher from Ajman University of Science and Technology. The author has contributed to research in topics: Cancellous bone & Bone mineral. The author has an hindex of 7, co-authored 15 publications receiving 147 citations. Previous affiliations of Emad S. Elsubeihi include University of Toronto & Johns Hopkins University.

Papers
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Journal ArticleDOI
TL;DR: BMD of the edentulous mandible following extraction of mandibular molars and the incisor on one side of the mandible increases up to 56 days, but that total bone volume increasesup to 112 days post-extraction indicates that bone volume measurement is more sensitive than BMD measurements in detecting small increase in bone formation at later stages of healing.

44 citations

Journal Article
TL;DR: A series of prospective studies started in the mid-1980s at the University of Toronto have provided evidence of the efficacy and effectiveness of implants in the treatment of the fully and partially edentulous patients as mentioned in this paper.
Abstract: A series of prospective studies started in the mid-1980s at the University of Toronto have provided evidence of the efficacy and effectiveness of implants in the treatment of the fully and partially edentulous patients. These studies have focused primarily on treatment outcomes at the surgical and prosthodontic levels, with an overall failure rate of 7.7% over a 20-year period. Because a considerable proportion of these failures (4.2%) occurred before insertion of the prosthesis, and because osseointegration is essentially a wound-healing process, factors that inter- fere with healing, including systemic conditions, may contribute to implant failure. This paper reviews studies on the impact of selected systemic conditions, including osteoporosis, cardiovascular diseases, diabetes mellitus, and hypothyroidism, as well as smoking behaviour, on the success or "survival" of oral implants in patients treated in the Implant Prosthodontic Unit at the University of Toronto.

42 citations

Journal ArticleDOI
01 Nov 2003-Bone
TL;DR: It is demonstrated that ovariectomy in rats results in a dramatic decrease in the number of both Dex- and Prog-dependent osteoprogenitors in cell populations from vertebrae and proximal femurs, and that estrogen clearly downregulated proliferation and differentiation of the Dex-dependent progenitors.

15 citations

Journal ArticleDOI
TL;DR: Bone turnover was increased by ovariectomy (OVX) as reflected by increased static parameters of bone formation and resorption, and Cancellous bone volume in the post-OVX group decreased more than that in the control group.

15 citations

Journal ArticleDOI
TL;DR: Prefabricated cross-linked posts with epoxy-based matrix demonstrated higher bond strength than prefabricatedCross- linked posts with Bis-GMA-based Matrix and posts with semi-IPN matrix when luted with dimethacrylate-based dual-cured resin cement.
Abstract: Objective. To evaluate the influence of 3 different post-resin matrix systems cemented with dual-cure resin cement in simulated root canals made of PMMA acrylic sheet. Methods. 3 types of fiber posts (n = 60) with different resin matrixes divided into 3 groups: group 1 cross-linked FRC Postec Plus post (n = 20), group 2 cross-linked Rely X post (n = 20), and group 3 Interpenetrated IPN Everstick post (n = 20). All posts were cemented using Multilink Automix dual-cure cement. Posts were cemented into acrylic blocks in order to purely test the strength of cement-post interface. After one week storage at 37°C, two sections of 1 mm thickness from middle-third were subjected to micro-push-out test at crosshead speed 0.5 mm/min. Results. The data were analyzed using one-way analysis of variance (ANOVA). The variable fiber post-matrix system was found to significantly affect the push-out bond strength ( ). Group 2 exhibited that the highest mean push-out bond strength was (5.36 + 2.3 MPa), and group 3 showed the lowest mean push-out (0.41 + 0.4 MPa). There was significant difference among the groups regarding the failure mode as chi-square test revealed ( ). Conclusion. Prefabricated cross-linked posts with epoxy-based matrix demonstrated higher bond strength than prefabricated cross-linked posts with Bis-GMA-based matrix and posts with semi-IPN matrix when luted with dimethacrylate-based dual-cured resin cement.

12 citations


Cited by
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Journal ArticleDOI
TL;DR: A successful dental implant osseointegration can be accomplished in subjects with diabetes with good metabolic control in a similar manner as in subjects without diabetes.
Abstract: Background: Implant treatment is an attractive substitute to traditional fixed/removable prosthetic appliances. In patients with diabetes, dental implant therapy has been considered a contraindication. Hyperglycemia augments the severity of periodontal disease, and glycemic control is an essential variable in determining the success of dental implants in subjects with diabetes. Subjects with well-controlled diabetes may not be significantly compromised and can have high dental implant success rates compared to individuals with poorly controlled diabetes. The focused questions addressed in this systematic review were as follows: Can patients with diabetes be good candidates for dental implant therapy? And how does hyperglycemia and glycemic control influence osseointegration? Methods: A systematic literature search of MEDLINE/PubMed articles published from 1982 up to and including July 2009 was independently performed by two investigators. In addition, reference lists of original and review articles were searched. The search strategy was to use the following terms in different combinations: dental implants, immediate implants, osseointegration, periodontal disease, diabetes, hyperglycemia, metabolic control, and glycemic control. The search included studies on humans and diabetes-induced animal models. The selection criteria included all levels of available evidence. Suitable variables included the implant survival rate among individuals with diabetes, effects of hyperglycemia and glycemic control on bone, and maintenance of dental implants in subjects with diabetes. Articles published only in the English language were considered, and unpublished data were not sought. Results: We initially identified 33 studies. Fifteen studies, which did not fulfill the selection criteria, were excluded. The included studies reported that poorly controlled diabetes negatively affects implant osseointegration; however, under optimal serum glycemic control, osseointegration can successfully occur in patients with diabetes. Animal studies have confirmed that osseointegration can be successfully achieved in insulincontrolled rats with diabetes, whereas in uncontrolled rats with diabetes, the bone-to-implant contact appears to decrease with time. The use of antiseptic mouthrinses and oral-hygiene maintenance helps in achieving a successful dental implant osseointegration in subjects with diabetes. Conclusion: A successful dental implant osseointegration can be accomplished in subjects with diabetes with good metabolic control (serum glycemic level and hemoglobin A1c in normal range) in a similar manner as in subjects without diabetes. J Periodontol 2009;80:1719-1730.

271 citations

Journal ArticleDOI
TL;DR: Evidence on the association between diabetes and periodontitis supports the concept of increased severity but not extent ofperiodontitis in subjects with poorly controlled diabetes, but the effects of periodontal therapy on glycaemic control and systemic inflammation need to be confirmed in large-scale randomized-controlled clinical trials.
Abstract: Objectives: To review the evidence for the association between diabetes and periodontal and peri-implant conditions and the impact of periodontal therapy in subjects with diabetes. Material and Methods: A search of MEDLINE-PubMed was performed up to and including December 2007. The search was limited to clinical studies published in English. Publications on animal studies were excluded. The selection criteria included all levels of available evidence. Results: Evidence on the association between diabetes and periodontitis supports the concept of increased severity but not extent of periodontitis in subjects with poorly controlled diabetes. Subjects with controlled diabetes do not show an increase in extent and severity of periodontitis. Periodontitis is associated with poor glycaemic control and diabetes-related complications. It is inconclusive that periodontal therapy with or without the use of antibiotics results in improvements of glycaemic control and of markers of systemic inflammation. Evidence is lacking to indicate that implant therapy in subjects with diabetes yields long-term outcomes comparable with those of nondiabetic subjects. Conclusions: Poorly controlled diabetes may be considered a risk factor for increased severity of periodontitis. The effects of periodontal therapy on glycaemic control and systemic inflammation is not proven beyond doubt and need to be confirmed in largescale randomized-controlled clinical trials.

254 citations

Journal ArticleDOI
TL;DR: It is shown that a tissue-resident adult stem cell population in vivo can be pharmacologically modified to promote a regenerative function in adult animals.
Abstract: Drug targeting of adult stem cells has been proposed as a strategy for regenerative medicine, but very few drugs are known to target stem cell populations in vivo. Mesenchymal stem/progenitor cells (MSCs) are a multipotent population of cells that can differentiate into muscle, bone, fat, and other cell types in context-specific manners. Bortezomib (Bzb) is a clinically available proteasome inhibitor used in the treatment of multiple myeloma. Here, we show that Bzb induces MSCs to preferentially undergo osteoblastic differentiation, in part by modulation of the bone-specifying transcription factor runt-related transcription factor 2 (Runx-2) in mice. Mice implanted with MSCs showed increased ectopic ossicle and bone formation when recipients received low doses of Bzb. Furthermore, this treatment increased bone formation and rescued bone loss in a mouse model of osteoporosis. Thus, we show that a tissue-resident adult stem cell population in vivo can be pharmacologically modified to promote a regenerative function in adult animals.

237 citations

Journal ArticleDOI
TL;DR: This book is clearly not intended for diagnostic histopathologists except for those with a special interest in the lymphoreticular system and neoplasms of that system and those who have good library facilities available will need to judge for themselves whether they consider it worthwhile paying £16-50 for having a literature survey covering that system.
Abstract: frequently that many pathologists now accept it as fact. The diagram showing cleaved cells progressing to non-cleaved cells reappears again in this issue. There is little factual evidence to support this sequence, and critical immunohistochemical studies on germinal follicles that show cytoplasmic immunoglobulin in cleaved but not in non-cleaved cells would argue against it. This book is clearly not intended for diagnostic histopathologists except for those with a special interest in the lymphoreticular system. Clinical and laboratory workers in the field of lymphoreticular disease, who do not have ready access to an Index Medicus, will certainly find this book useful. Those who have good library facilities available will need to judge for themselves whether they consider it worthwhile paying £16-50 for having a literature survey covering the lymphoreticular system and neoplasms of that system. The apparent continued popularity of this series indicates that most workers consider this money well spent. For their sakes one hopes that Dr Taylor and his colleagues will continue to find the energy and time to undertake this formidable annual task but that they might be a little more critical of the material reviewed.

168 citations

Journal ArticleDOI
29 Jun 2012-PLOS ONE
TL;DR: A model in which the Th17 subset of T-lymphocytes produces IL-17F to stimulate bone healing is proposed, which in turn may aid in optimizing fracture management and in the treatment of impaired bone healing.
Abstract: While it is well known that the presence of lymphocytes and cytokines are important for fracture healing, the exact role of the various cytokines expressed by cells of the immune system on osteoblast biology remains unclear. To study the role of inflammatory cytokines in fracture repair, we studied tibial bone healing in wild-type and Rag1−/− mice. Histological analysis, µCT stereology, biomechanical testing, calcein staining and quantitative RNA gene expression studies were performed on healing tibial fractures. These data provide support for Rag1−/− mice as a model of impaired fracture healing compared to wild-type. Moreover, the pro-inflammatory cytokine, IL-17F, was found to be a key mediator in the cellular response of the immune system in osteogenesis. In vitro studies showed that IL-17F alone stimulated osteoblast maturation. We propose a model in which the Th17 subset of T-lymphocytes produces IL-17F to stimulate bone healing. This is a pivotal link in advancing our current understanding of the molecular and cellular basis of fracture healing, which in turn may aid in optimizing fracture management and in the treatment of impaired bone healing.

137 citations