Author
Eman J. El-Agroudy
Bio: Eman J. El-Agroudy is an academic researcher from Alexandria University. The author has contributed to research in topics: Celecoxib & Plasmodium berghei. The author has an hindex of 2, co-authored 3 publications receiving 99 citations.
Papers
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TL;DR: A new series of pyrazole derivatives synthesized by hybridization with five-membered heterocyclic moieties exhibited dual activity against malaria and leishmaniasis and were safe and well tolerated by the experimental animals orally up to 300mg/kg and parenterally up to 100 mg/kg.
88 citations
TL;DR: This review focuses on recent findings in drugs used for the treatment of leishmaniasis including; chemical and natural antileishmanial moieties, different potential targets, as well as various trials of vaccination development.
55 citations
TL;DR: In this article, the authors evaluated the therapeutic activity and adverse drug reactions associated with the use of the newly synthesized pyrazole derivative, compound AD732, E-4-[3-(4-methylphenyl)-5-hydroxyliminomethyl-1H-pyrazol-1-yl]benzenesulfonamide, as compared to indomethacin and celecoxib as standard agents.
14 citations
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TL;DR: The different synthesis methods and the pharmacological properties of pyrazole derivatives developed by many scientists around the globe are highlighted.
Abstract: Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antipsychotic CDPPB, the anti-obesity drug rimonabant, difenamizole, an analgesic, betazole, a H2-receptor agonist and the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Owing to this diversity in the biological field, this nucleus has attracted the attention of many researchers to study its skeleton chemically and biologically. This review highlights the different synthesis methods and the pharmacological properties of pyrazole derivatives. Studies on the synthesis and biological activity of pyrazole derivatives developed by many scientists around the globe are reported.
520 citations
TL;DR: Owing to the development of novel and new pyrazole based therapeutic agents at a faster pace, there is a need to couple the latest information with previously available information to understand status of this moiety in medicinal chemistry research.
286 citations
TL;DR: This review examines recent publications relating the structures of pyrazoles with their corresponding biological activities and approved pyrazole-containing drugs.
254 citations
TL;DR: This review covers the main research published between early 2013 to mid-2015 and takes into account several previous reviews on the subject, with particular attention given to anticancer hybrids.
Abstract: Introduction: The hybridization of biologically active molecules is a powerful tool for drug discovery used to target a variety of diseases. It offers the prospect of better drugs for the treatment of a number of illnesses including cancer, malaria, tuberculosis and AIDS. Hybrid drugs can provide combination therapies in a single multi-functional agent and, by doing so, be more specific and powerful than conventional classic treatments. This research field is in great expansion and attracts many researchers worldwide.Area covered: This review covers the main research published between early 2013 to mid-2015 and takes into account several previous reviews on the subject. Its intention is to showcase the most recent advances reported towards the development of molecular hybrids in drug discovery. Particular attention is given to anticancer hybrids throughout the review.Expert opinion: Current advances show that molecular hybrids of biologically active molecules can lead to powerful therapeutics. Nat...
197 citations
TL;DR: An overview of recent literature is presented to provide imminent into the applications of different heterocyclic scaffolds in fighting against malaria.
192 citations