Emiko Urano

TL;DR: It is hypothesized that CXCR4 distributes to the cell surface as a multimer, in order to effectively sense, with increased avidity, the chemotaxis‐inducing ligand in the microenvironment, and this is the first report providing direct experimental evidence for the higher‐order multimerization of CX CR4 in vivo.

TL;DR: The authors combine NMR spectroscopy, cryo-EM, and molecular dynamics simulations to provide insight into the conformational equilibria in CA-SP1 assemblies relevant to HIV-1 maturation intermediates formation.

TL;DR: Stapled peptides, a new class of stabilized α-helical peptidomimetics were adopted to enhance the cell permeability of the above lead peptides and led to a remarkable increase in their potency in cells and a significant reduction of their cytotoxicity.

TL;DR: Alkyl amine derivatives modified at the C-28 position of the BVM scaffold are identified that are markedly more potent than BVM against an HIV-1 clade B clone and show robust antiviral activity against a variant of NL4-3 containing the V7A polymorphism in SP1.

TL;DR: High‐throughput cytokine profiling might be a valuable tool for the differential diagnosis ofEBV‐associated B cell lymphomas and might deepen the understanding of the pathogenesis of EBV‐ associated B cell malignancies.