Emily A. Peterson

Bio: Emily A. Peterson is an academic researcher from Amgen. The author has contributed to research in topics: Total synthesis & Enantioselective synthesis. The author has an hindex of 21, co-authored 50 publications receiving 1774 citations. Previous affiliations of Emily A. Peterson include Harvard University & Universidade Federal do Rio Grande do Sul.

Enantioselective Pictet-Spengler-type cyclizations of hydroxylactams: H-bond donor catalysis by anion binding.

Abstract: Highly enantioenriched indolizinone and quinolizinone products are obtained in the thiourea-catalyzed cyclization of tryptamine-derived hydroxylactams. Substituent and counterion effect studies point to a novel mechanism of catalysis involving rate-limiting anion abstraction and binding by the thiourea.

Contiguous stereogenic quaternary carbons: A daunting challenge in natural products synthesis

Abstract: One element of structure that invariably increases the difficulty of a chemical synthesis is the presence in the target molecule of contiguous all-carbon quaternary stereocenters. This Perspective will examine the most useful transformations and strategies devised recently for directly assembling this structural unit.

Sustainable Practices in Medicinal Chemistry: Current State and Future Directions

Abstract: The medicinal chemistry subgroup of the American Chemical Society’s Green Chemistry Institute Pharmaceutical Roundtable (ACS GCI PR) offers a perspective on the current state of environmentally sustainable practices in medicinal chemistry with the aim of sharing best practices more widely and highlighting some potential future developments.

Fisheries management impacts on target species status

Abstract: Fisheries management systems around the world are highly diverse in their design, operation, and effectiveness at meeting objectives. A variety of management institutions, strategies, and tactics are used across disparate regions, fishing fleets, and taxonomic groups. At a global level, it is unclear which particular management attributes have greatest influence on the status of fished populations, and also unclear which external factors affect the overall success of fisheries management systems. We used expert surveys to characterize the management systems by species of 28 major fishing nations and examined influences of economic, geographic, and fishery-related factors. A Fisheries Management Index, which integrated research, management, enforcement, and socioeconomic attributes, showed wide variation among countries and was strongly affected by per capita gross domestic product (positively) and capacity-enhancing subsidies (negatively). Among 13 management attributes considered, three were particularly influential in whether stock size and fishing mortality are currently in or trending toward desirable states: extensiveness of stock assessments, strength of fishing pressure limits, and comprehensiveness of enforcement programs. These results support arguments that the key to successful fisheries management is the implementation and enforcement of science-based catch or effort limits, and that monetary investment into fisheries can help achieve management objectives if used to limit fishing pressure rather than enhance fishing capacity. Countries with currently less-effective management systems have the greatest potential for improving long-term stock status outcomes and should be the focus of efforts to improve fisheries management globally.

Enantioselective, thiourea-catalyzed intermolecular addition of indoles to cyclic N-acyl iminium ions.

Abstract: The discovery that chiral hydrogen-bond donors effectively promote highly enantioselective reactions of cationic intermediates has opened a new direction within the field of organocatalysis.[1,2] For example, the discovery of thiourea-catalyzed enantioselective acyl-Pictet–Spengler-type cyclizations has helped bring N-acyliminium ions into the realm of viable substrates for asymmetric catalysis.[2a-d,2f,3] Harnessing N-acyliminium ions for enantioselective intermolecular addition of indoles (e.g., eq. 1) would allow direct access to functionalized indole frameworks with established biological activity,[4] and also provide useful precursors to more complex alkaloid natural product targets.[5] There have been several recent reports of intermolecular asymmetric catalytic additions of indoles to acyclic imines.[6] In most cases, the electrophilic partners have been limited to substituted benzaldehyde derivatives, although Deng and coworkers also identified successful reactions with a variety of acyclic aliphatic imines.[6c] Herein we report highly enantioselective intermolecular additions of indoles to hydroxylactam-derived cyclic N-acyliminium ions catalyzed by a new thiourea-Schiff base derivative. (1) We selected as a model reaction the addition of indole to succinimide-derived hydroxylactam 1, a bench-stable, storable compound that was easily prepared and handled (eq. 2).7 A variety of thiourea and urea catalyst frameworks were evaluated as potential catalysts under conditions similar to those developed for the related intramolecular acyl-Pictet–Spengler cyclization (Table 1).2c A promising lead result was obtained in the reaction promoted by Schiff-base 4a8 in TBME at −30 °C, with adduct 2a generated in 55% ee and 30% yield (entry 2). No background reactivity was observed under these conditions in the absence of catalyst. Interestingly, pyrrole derivative 3, the optimal catalyst identified for the intramolecular acyl-Pictet–Spengler reaction,2c afforded the opposite enantiomer in low ee (entry 1). Table 1 Catalyst Optimization Studies Systematic variation of the catalyst structure around the basic framework of 4 led to substantial improvements in reaction enantioselectivity (Table 1). Diaminocyclohexane-derived catalysts were examined bearing different Schiff-base, amide, and amino acid side chain components. The primary amine resulting from hydrolysis of Schiff base 4a was found to be catalytically active, but afforded racemic product. Thus, we recognized that maintaining the integrity of the Schiff base throughout the reaction would be essential to obtaining high enantioselectivity. After extensive experimentation, it was found that catalyst 4g, bearing a triethylsilyl group at R4 and a tert-butyl group at R5, promoted formation of 2a with slightly higher enantioselectivity relative to catalyst 4a (65% vs. 55% ee). Further improvement in enantioselectivity was achieved by introduction of a stereochemical element at the benzylic position of the amide, with the (R)-methyl catalyst 4i providing 2a in 80% ee (entry 10). While the majority of effective thiourea catalysts identified to date contain a tert-leucine backbone (R3 = tBu),[9] catalyst 4j derived from phenylalanine proved substantially more enantioselective than tert-leucine analog 4i (89 vs 80% ee, entry 11). Finally, constraining the chiral amide component in a cyclic framework as in catalyst 5 led to additional improvement in enantioselectivity, with generation of 2a in 93% ee (entry 12).[10-12] (2) Despite the high ee's obtained with catalyst 5, the efficiency of product formation using hydroxylactam 1 was quite modest (30–40% conversion with 10 mol% catalyst). This was attributable, at least in part, to the poor solubility of 1 under the reaction conditions, so several derivatives of the hydroxylactam substrate were prepared with the aim of discovering a more suitable N-acyliminium ion precursor. Acetyl derivative 6a, prepared by acylation of 1, displayed improved solubility and underwent conversion to 2a in 93%ee and 71% isolated yield (Table 2). Table 2 Alkylation of Electron-Rich Indole Substrates[a] No reaction was observed in the absence of TMSCl or other acidic additive, and comparison of different TMS-X reagents revealed that the chloride counteranion was uniquely effective for achieving high enantioselectivity.[13-14] Use of BCl3 as an additive in place of TMSCl led to complete substrate conversion after only 8 hours, albeit with slightly diminished ee (91 vs. 93% ee). The presence of controlled amounts of added water in the TMSCl-promoted reactions also had a pronounced beneficial effect on reactivity.[15] Best results were obtained using 5 mol% catalyst 5, two equivalents of TMSCl in anhydrous TBME, and 8 mol% water, and allowing the reaction to proceed for 24 h at −30 °C. Under these conditions, adduct 2 was generated reproducibly in 93% ee and 84% isolated yield. The synergistic effect of TMSCl and catalytic H2O[16] suggests that acetoxylactam 6 undergoes reaction with in situ-generated HCl to form chlorolactam 7, and that this equilibrium is driven by trapping the acetic acid byproduct with TMSCl.[17] We propose that racemic chlorolactam 7 is the actual substrate in the alkylation, and that the reaction proceeds via an SN1-type anion-binding mechanism analogous to that proposed for related thiourea-catalyzed acyl-Pictet–Spengler and oxocarbenium ion alkylation reactions (Scheme 1).[2c-e] Scheme 1 Proposed catalytic cycle With a reliable protocol in hand, the scope of the reaction was investigated. Under the optimized conditions, a variety of electron-rich indoles were shown to add to both succinimide and glutarimide-derived electrophiles with high enantioselectivity (Table 2).[18] Consistent results were obtained over a ten-fold increase in the scale of the reaction (entry 1). In several cases, we found that the enantiomeric enrichment of the products could be increased simply by trituration.[19] Encouraged by the scope of the addition with electron-rich indoles, electron-deficient indoles were examined as well. Using the optimized TMSCl conditions, these substrates provided adducts in high enantioselectivity, but in low yield. In contrast, for halogenated indole substrates, the use of 10 mol % BCl3 in the presence of 10 mol% 5 afforded useful yields and high enantioselectivity of products 2m–2u (Table 3). Table 3 Alkylation of Electron-Deficient Indoles In summary, we have developed a highly enantioselective addition of indoles to cyclic N-acyliminium ions using a chiral thiourea Schiff-base catalyst. The scope includes both electron-rich and electron-poor indole nucleophiles. The products are synthetically useful intermediates and are readily elaborated: for example, cleavage of the benzyl protecting group using Na/NH3 proceeds without erosion of enantiomeric excess.[19] Efforts to apply anion-binding principles to other reactions involving cationic intermediates are underway.

The advent and development of organocatalysis

Abstract: The use of small organic molecules as catalysts has been known for more than a century. But only in the past decade has organocatalysis become a thriving area of general concepts and widely applicable asymmetric reactions. Here I present my opinion on why the field of organocatalysis has blossomed so dramatically over the past decade.

Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions

Abstract: Pd-catalyzed cross-coupling reactions that form C–N bonds have become useful methods to synthesize anilines and aniline derivatives, an important class of compounds throughout chemical research. A key factor in the widespread adoption of these methods has been the continued development of reliable and versatile catalysts that function under operationally simple, user-friendly conditions. This review provides an overview of Pd-catalyzed N-arylation reactions found in both basic and applied chemical research from 2008 to the present. Selected examples of C–N cross-coupling reactions between nine classes of nitrogen-based coupling partners and (pseudo)aryl halides are described for the synthesis of heterocycles, medicinally relevant compounds, natural products, organic materials, and catalysts.