E
Emily O. Kistner
Researcher at University of Chicago
Publications - 43
Citations - 9857
Emily O. Kistner is an academic researcher from University of Chicago. The author has contributed to research in topics: Single-nucleotide polymorphism & International HapMap Project. The author has an hindex of 31, co-authored 43 publications receiving 9457 citations. Previous affiliations of Emily O. Kistner include University of North Carolina at Chapel Hill & National Institutes of Health.
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Journal ArticleDOI
A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
Richard H. Duerr,Kent D. Taylor,Steven R. Brant,Steven R. Brant,John D. Rioux,John D. Rioux,Mark S. Silverberg,Mark J. Daly,Mark J. Daly,A. Hillary Steinhart,Clara Abraham,Miguel Regueiro,Anne M. Griffiths,Themistocles Dassopoulos,Alain Bitton,Huiying Yang,Stephan R. Targan,Lisa W. Datta,Emily O. Kistner,L. Philip Schumm,Annette Lee,Peter K. Gregersen,M. Michael Barmada,Jerome I. Rotter,Dan L. Nicolae,Judy H. Cho +25 more
TL;DR: A highly significant association is found between Crohn's disease and the IL23R gene on chromosome 1p31, which encodes a subunit of the receptor for the proinflammatory cytokine interleukin-23, which prioritize this signaling pathway as a therapeutic target in inflammatory bowel disease.
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Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Jeffrey C. Barrett,Sarah Hansoul,Dan L. Nicolae,Judy H. Cho,Richard H. Duerr,John D. Rioux,John D. Rioux,Steven R. Brant,Mark S. Silverberg,Kent D. Taylor,M. Michael Barmada,Alain Bitton,Themistocles Dassopoulos,Lisa W. Datta,Todd Green,Anne M. Griffiths,Emily O. Kistner,Michael T. Murtha,Miguel Regueiro,Jerome I. Rotter,L. Philip Schumm,A. Hillary Steinhart,Stephan R. Targan,Ramnik J. Xavier,Cécile Libioulle,Cynthia Sandor,Mark Lathrop,Jacques Belaiche,Olivier Dewit,Ivo Gut,Simon Heath,Debby Laukens,Myriam Mni,Paul Rutgeerts,André Van Gossum,Diana Zelenika,Denis Franchimont,Jean-Pierre Hugot,Martine De Vos,Severine Vermeire,Edouard Louis,Lon R. Cardon,Carl A. Anderson,Hazel E. Drummond,Elaine R. Nimmo,Tariq Ahmad,Natalie J. Prescott,Clive M. Onnie,Sheila A. Fisher,Jonathan Marchini,Jilur Ghori,Suzannah Bumpstead,Rhian Gwilliam,Mark Tremelling,Panos Deloukas,John C. Mansfield,Derek P. Jewell,Jack Satsangi,Christopher G. Mathew,Miles Parkes,Michel Georges,Mark J. Daly,Mark J. Daly +62 more
TL;DR: The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1, which offer promise for informed therapeutic development.
Journal ArticleDOI
Let-7 expression defines two differentiation stages of cancer.
Scott A. Shell,Sun Mi Park,Amir Reza Radjabi,Robert Schickel,Emily O. Kistner,David Jewell,Christine Feig,Ernst Lengyel,Marcus E. Peter +8 more
TL;DR: Using ovarian cancer as a model, expression of let-7 and HMGA2 is a better predictor of prognosis than classical markers such as E-cadherin, vimentin, and Snail, and data identify loss ofLet-7 expression as a marker for less differentiated cancer.
Journal ArticleDOI
Ulcerative colitis–risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
Mark S. Silverberg,Judy H. Cho,John D. Rioux,Dermot P.B. McGovern,Jing Wu,Vito Annese,Jean Paul Achkar,Philippe Goyette,Regan Scott,Wei Xu,M. Michael Barmada,Lambertus Klei,Mark J. Daly,Clara Abraham,Theodore M. Bayless,Fabrizio Bossa,Anne M. Griffiths,Andrew Ippoliti,Raymond G. Lahaie,Anna Latiano,Pierre Paré,Deborah D. Proctor,Miguel Regueiro,A. Hillary Steinhart,Stephan R. Targan,L. Philip Schumm,Emily O. Kistner,Annette Lee,Peter K. Gregersen,Jerome I. Rotter,Steven R. Brant,Kent D. Taylor,Kathryn Roeder,Richard H. Duerr +33 more
TL;DR: Combined genome-wide significant evidence for association was found in a region spanning BTNL2 to HLA-DQB1 on chromosome 6p21 and at the IL23R locus on chromosome 1p31, and in an analysis that controlled for gender and population structure.
Journal ArticleDOI
Loss of E-Cadherin Promotes Ovarian Cancer Metastasis via α5-Integrin, which Is a Therapeutic Target
Kenjiro Sawada,Anirban K. Mitra,A. Reza Radjabi,Vinay Bhaskar,Emily O. Kistner,Maria Tretiakova,Sujatha Jagadeeswaran,Anthony G. Montag,Amy R. Becker,Hilary A. Kenny,Marcus E. Peter,Vanitha Ramakrishnan,S. Diane Yamada,Ernst Lengyel +13 more
TL;DR: It is shown here that inhibition of E-cadherin in ovarian cancer cells causes up-regulation of alpha(5)-integrin protein expression and transcription, providing an explanation for how E- cadher in loss increases metastasis.