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Emmanuelle Bouzigon
Researcher at Paris Diderot University
Publications - 61
Citations - 4381
Emmanuelle Bouzigon is an academic researcher from Paris Diderot University. The author has contributed to research in topics: Asthma & Genome-wide association study. The author has an hindex of 27, co-authored 58 publications receiving 3881 citations. Previous affiliations of Emmanuelle Bouzigon include University of Évry Val d'Essonne & French Institute of Health and Medical Research.
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Journal ArticleDOI
A large-scale, consortium-based genomewide association study of asthma.
Miriam F. Moffatt,Ivo Gut,Florence Demenais,David P. Strachan,Emmanuelle Bouzigon,Simon Heath,Erika von Mutius,Martin Farrall,Mark Lathrop,William O.C.M. Cookson +9 more
TL;DR: A few common alleles are associated with disease risk at all ages and suggest a role for communication of epithelial damage to the adaptive immune system and activation of airway inflammation in asthma.
Journal ArticleDOI
Effect of 17q21 variants and smoking exposure in early-onset asthma.
Emmanuelle Bouzigon,Eve Corda,Hugues Aschard,Marie-Hélène Dizier,Anne Boland,Jean Bousquet,Nicolas Chateigner,Frédéric Gormand,Jocelyne Just,Nicole Le Moual,Pierre Scheinmann,Valérie Siroux,Daniel Vervloet,Diana Zelenika,Isabelle Pin,Francine Kauffmann,G. Mark Lathrop,Florence Demenais +17 more
TL;DR: This study shows that the increased risk of asthma conferred by 17q21 genetic variants is restricted to early-onset asthma and that the risk is further increased by early-life exposure to environmental tobacco smoke.
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
Florence Demenais,Patricia Margaritte-Jeannin,Kathleen C. Barnes,William O.C.M. Cookson,Janine Altmueller,Wei Ang,R. Graham Barr,Terri H. Beaty,Allan B. Becker,John Beilby,Hans Bisgaard,Unnur S. Bjornsdottir,Eugene R. Bleecker,Klaus Bønnelykke,Dorret I. Boomsma,Emmanuelle Bouzigon,Christopher E. Brightling,Myriam Brossard,Guy Brusselle,Esteban G. Burchard,Kristin M. Burkart,Andrew Bush,Moira Chan-Yeung,Kian Fan Chung,Alexessander Couto Alves,John A. Curtin,Adnan Custovic,Denise Daley,Johan C. de Jongste,Blanca E. Del-Rio-Navarro,Kathleen M. Donohue,Liesbeth Duijts,Celeste Eng,Johan G. Eriksson,Martin Farrall,Yuliya Fedorova,Bjarke Feenstra,Manuel A. R. Ferreira,Maxim B. Freidin,Zofia K. Z. Gajdos,Jim Gauderman,Ulrike Gehring,Frank Geller,Jon Genuneit,Sina A. Gharib,Frank D. Gilliland,Raquel Granell,Penelope E. Graves,Daniel F. Gudbjartsson,Tari Haahtela,Susan R. Heckbert,Dick Heederik,Joachim Heinrich,Markku Heliövaara,John Henderson,Blanca E. Himes,Hiroshi Hirose,Joel N. Hirschhorn,Albert Hofman,Patrick G. Holt,Jouke J. Hottenga,Thomas J. Hudson,Jennie Hui,Medea Imboden,Vladimir P. Ivanov,Vincent W. V. Jaddoe,Alan James,Christer Janson,Marjo-Riitta Järvelin,Deborah Jarvis,Graham Jones,Ingileif Jonsdottir,Pekka Jousilahti,Michael Kabesch,Mika Kähönen,David B. Kantor,A. S. Karunas,Elza Khusnutdinova,Gerard H. Koppelman,Anita L. Kozyrskyj,Eskil Kreiner,Michiaki Kubo,Rajesh Kumar,Ashok Kumar,Mikko Kuokkanen,Lies Lahousse,Tarja Laitinen,Catherine Laprise,Mark Lathrop,Susanne Lau,Young-Ae Lee,Terho Lehtimäki,Sébastien Letort,Albert M. Levin,Guo Li,Liming Liang,Laura R. Loehr,Stephanie J. London,Daan W. Loth,Ani Manichaikul,Ingo Marenholz,Fernando J. Martinez,Melanie C. Matheson,Rasika A. Mathias,Kenji Matsumoto,Hamdi Mbarek,Wendy L. McArdle,Mads Melbye,Erik Melén,Deborah A. Meyers,Sven Michel,Hamida Mohamdi,Arthur W. Musk,Rachel A. Myers,Maartje A.E. Nieuwenhuis,Emiko Noguchi,George T. O'Connor,Ludmila M. Ogorodova,Cameron D. Palmer,Aarno Palotie,Julie E. Park,Craig E. Pennell,Göran Pershagen,Alexey Polonikov,Dirkje S. Postma,Nicole Probst-Hensch,V. P. Puzyrev,Benjamin A. Raby,Olli T. Raitakari,Adaikalavan Ramasamy,Stephen S. Rich,Colin F. Robertson,Isabelle Romieu,Muhammad T. Salam,Veikko Salomaa,Vivi Schlünssen,Robert A. Scott,P. A. Selivanova,Torben Sigsgaard,Angela Simpson,Valérie Siroux,Lewis J. Smith,Maria Solodilova,Marie Standl,Kari Stefansson,David P. Strachan,Bruno H. Stricker,Atsushi Takahashi,Philip J. Thompson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Carla M. T. Tiesler,Dara G. Torgerson,Tatsuhiko Tsunoda,André G. Uitterlinden,Ralf J. P. van der Valk,Amaury Vaysse,Sailaja Vedantam,Andrea von Berg,Erika von Mutius,Judith M. Vonk,Johannes Waage,Nicholas J. Wareham,Scott T. Weiss,Wendy B. White,Magnus Wickman,Elisabeth Widen,Gonneke Willemsen,L. Keoki Williams,Inge M. Wouters,James J. Yang,Jing Hua Zhao,Miriam F. Moffatt,Carole Ober,Dan L. Nicolae +174 more
Journal ArticleDOI
Meta-analysis identifies seven susceptibility loci involved in the atopic march
Ingo Marenholz,Ingo Marenholz,Jorge Esparza-Gordillo,Jorge Esparza-Gordillo,Franz Rüschendorf,Anja Bauerfeind,David P. Strachan,Ben D. Spycher,Hansjörg Baurecht,Patricia Margaritte-Jeannin,Patricia Margaritte-Jeannin,Annika Sääf,Marjan Kerkhof,Markus J. Ege,Svetlana Baltic,Melanie C. Matheson,Jin Li,Sven Michel,Wei Ang,Wendy L. McArdle,Andreas Arnold,Georg Homuth,Florence Demenais,Florence Demenais,Emmanuelle Bouzigon,Emmanuelle Bouzigon,Cilla Söderhäll,Göran Pershagen,Johan C. de Jongste,Dirkje S. Postma,Charlotte Braun-Fahrländer,Elisabeth Horak,Ludmila M. Ogorodova,V. P. Puzyrev,Elena Yu. Bragina,Thomas J. Hudson,Charles Morin,David L. Duffy,Guy B. Marks,Colin F. Robertson,Grant W. Montgomery,Bill Musk,Philip J. Thompson,Nicholas G. Martin,Alan L. James,Patrick M. A. Sleiman,Patrick M. A. Sleiman,Elina Toskala,Elke Rodriguez,Regina Fölster-Holst,Andre Franke,Wolfgang Lieb,Christian Gieger,Andrea Heinzmann,Ernst Rietschel,Thomas Keil,Thomas Keil,Sven Cichon,Markus M. Nöthen,Craig E. Pennell,Peter D. Sly,Carsten Oliver Schmidt,Anja Matanovic,Anja Matanovic,Valentin Schneider,Matthias Heinig,Matthias Heinig,Norbert Hubner,Patrick G. Holt,Patrick G. Holt,Susanne Lau,Michael Kabesch,S. Weidinger,Hakon Hakonarson,Hakon Hakonarson,Manuel A. R. Ferreira,Catherine Laprise,Maxim B. Freidin,Jon Genuneit,Gerard H. Koppelman,Erik Melén,Erik Melén,Marie Hélène Dizier,Marie Hélène Dizier,A. John Henderson,Young-Ae Lee,Young-Ae Lee +86 more
TL;DR: It is suggested that eczema may play an important role in the development of asthma after Eczema, and two novel loci specific for the combined ecZema plus asthma phenotype are reported, which are associated with allergic disease for the first time.
Journal ArticleDOI
CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults.
Lidwien A.M. Smit,Valérie Siroux,Emmanuelle Bouzigon,Marie-Pierre Oryszczyn,Mark Lathrop,Florence Demenais,Francine Kauffmann +6 more
TL;DR: TLR2 and CD14 SNPs were associated with asthma and atopic asthma respectively, andCD14, TLR2,TLR4, and TLR9 SNPs modified associations between country living and asthma.