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Emmanuelle Charafe-Jauffret
Researcher at Aix-Marseille University
Publications - 168
Citations - 16611
Emmanuelle Charafe-Jauffret is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 53, co-authored 156 publications receiving 15130 citations. Previous affiliations of Emmanuelle Charafe-Jauffret include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Journal ArticleDOI
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.
Christophe Ginestier,Min Hee Hur,Emmanuelle Charafe-Jauffret,Florence Monville,Julie Dutcher,Marty Brown,Jocelyne Jacquemier,Patrice Viens,Celina G. Kleer,Suling Liu,Anne F. Schott,Daniel F. Hayes,Daniel Birnbaum,Max S. Wicha,Gabriela Dontu +14 more
TL;DR: It is shown that normal and cancer human mammary epithelial cells with increased aldehyde dehydrogenase activity (ALDH) have stem/progenitor properties and these cells contain the subpopulation of normal breast epithelium with the broadest lineage differentiation potential and greatest growth capacity in a xenotransplant model.
Journal ArticleDOI
Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature.
Emmanuelle Charafe-Jauffret,Christophe Ginestier,Flora Iovino,Julien Wicinski,Nathalie Cervera,Pascal Finetti,Min-Hee Hur,Mark E. Diebel,Florence Monville,Julie Dutcher,Marthy Brown,Patrice Viens,Luc Xerri,François Bertucci,Giorgio Stassi,Gabriela Dontu,Daniel Birnbaum,Max S. Wicha +17 more
TL;DR: It is shown that ALDEFLUOR-positive cells are responsible for mediating metastasis and the hierarchical organization of immortalized cell lines, establish techniques that can facilitate the characterization of regulatory pathways of CSCs, and identify potential stem cell markers and therapeutic targets.
Journal ArticleDOI
Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts
Suling Liu,Yang Cong,Dong Wang,Yu-Min Sun,Lu Deng,Yajing Liu,Rachel Martin-Trevino,Li Shang,Sean P. McDermott,Melissa D. Landis,Su-Hyung Hong,April Adams,Rosemarie C. D'Angelo,Christophe Ginestier,Emmanuelle Charafe-Jauffret,Shawn G. Clouthier,Daniel Birnbaum,Stephen T. C. Wong,Ming Zhan,Jenny C. Chang,Max S. Wicha +20 more
TL;DR: It is proposed that the plasticity of BCSCs that allows them to transition between EMT- and MET-like states endows these cells with the capacity for tissue invasion, dissemination, and growth at metastatic sites.
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CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
Christophe Ginestier,Suling Liu,Mark E. Diebel,Hasan Korkaya,Ming Luo,Marty Brown,Julien Wicinski,Olivier Cabaud,Emmanuelle Charafe-Jauffret,Daniel Birnbaum,Jun-Lin Guan,Gabriela Dontu,Max S. Wicha +12 more
TL;DR: The development of a strategy to target these breast cancer stem cells (CSCs) through blockade of the IL-8 receptor CXCR1 and repertaxin was able to specifically target the CSC population in human breast cancer xenografts, retarding tumor growth and reducing metastasis.
Journal ArticleDOI
Aldehyde Dehydrogenase 1–Positive Cancer Stem Cells Mediate Metastasis and Poor Clinical Outcome in Inflammatory Breast Cancer
Emmanuelle Charafe-Jauffret,Christophe Ginestier,Flora Iovino,Carole Tarpin,Mark E. Diebel,Benjamin Esterni,Gilles Houvenaeghel,Jean-Marc Extra,François Bertucci,François Bertucci,Jocelyne Jacquemier,Luc Xerri,Luc Xerri,Gabriela Dontu,Giorgio Stassi,Yi Xiao,Sanford H. Barsky,Daniel Birnbaum,Patrice Viens,Max S. Wicha +19 more
TL;DR: AlDH1 expression represents the first independent prognostic marker to predict metastasis and poor patient outcome in IBC and suggests that the metastatic, aggressive behavior of IBC may be mediated by a CSC component that displays ALDH enzymatic activity.