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Enrique L. Michelotti

Bio: Enrique L. Michelotti is an academic researcher. The author has contributed to research in topics: Grignard reaction & Nickel. The author has an hindex of 11, co-authored 13 publications receiving 964 citations.

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TL;DR: Etude de la substitution de groupes alcoxy d'enols ethers (methoxy-1 cyclohexenes, methoxy- 1 alcenes-1, benzofuranne, dihydro-2,3 furanne) par l'intermediaire de la reaction de Grignard catalysee par le dichlorure de bis-triphenylphosphine-nickel
Abstract: Etude de la substitution de groupes alcoxy d'enols ethers (methoxy-1 cyclohexenes, methoxy-1 alcenes-1, benzofuranne, dihydro-2,3 furanne) et de (methyl aryl) ethers par l'intermediaire de la reaction de Grignard catalysee par le dichlorure de bis-triphenylphosphine-nickel

201 citations

Journal ArticleDOI
TL;DR: In this article, the reactions of alkenyl sulphides, benzenethiols, and aryl sulphides with methylmagnesium, mediated by bis(triphenylphosphine)nickel dichloride, in benzene solution have been shown to lead to olefins (predominantly with retention of configuration), toluenes, and biphenyls in medium to high yields.
Abstract: The reactions of alkenyl sulphides, benzenethiols, and aryl sulphides with methylmagnesium and arylmagnesium bromides, mediated by bis(triphenylphosphine)nickel dichloride, in benzene solution have been shown to lead to olefins (predominantly with retention of configuration), toluenes, and biphenyls in medium to high yields.

166 citations


Cited by
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TL;DR: This paper presents a new state-of-the-art implementation of the iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Key Laborotary of Catalysis, which automates the very labor-intensive and therefore expensive and therefore time-heavy and expensive process ofalysis.
Abstract: and Fuels Changzhi Li,† Xiaochen Zhao,† Aiqin Wang,† George W. Huber,†,‡ and Tao Zhang*,† †State Key Laborotary of Catalysis, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China ‡Department of Chemical and Biological Engineering, University of WisconsinMadison, Madison, Wisconsin 53706, United States

1,977 citations

Journal ArticleDOI
TL;DR: This Review highlights the recent progress in the field of cross-dehydrogenative C sp 3C formations and provides a comprehensive overview on existing procedures and employed methodologies.
Abstract: Over the last decade, substantial research has led to the introduction of an impressive number of efficient procedures which allow the selective construction of CC bonds by directly connecting two different CH bonds under oxidative conditions. Common to these methodologies is the generation of the reactive intermediates in situ by activation of both CH bonds. This strategy was introduced by the group of Li as cross-dehydrogenative coupling (CDC) and discloses waste-minimized synthetic alternatives to classic coupling procedures which rely on the use of prefunctionalized starting materials. This Review highlights the recent progress in the field of cross-dehydrogenative C sp 3C formations and provides a comprehensive overview on existing procedures and employed methodologies.

1,528 citations

Journal ArticleDOI
TL;DR: This Review emphasizes the achievements in the selective catalytic functionalization of indoles (C-C bond-forming processes) over the last four years.
Abstract: 140 years ago Adolf von Baeyer proposed the structure of a heteroaromatic compound which revolutionized organic and medical chemistry: indole. After more than a century, indole itself and the complexity of naturally occurring indole derivatives continue to inspire and influence developments in synthetic chemistry. In particular, the ubiquitous presence of indole rings in pharmaceuticals, agrochemicals, and functional materials are testament to the ever increasing interest in the design of mild and efficient synthetic routes to functionalized indole derivatives. This Review emphasizes the achievements in the selective catalytic functionalization of indoles (C-C bond-forming processes) over the last four years.

1,141 citations