Erhan Pişkin

Bio: Erhan Pişkin is an academic researcher from Hacettepe University. The author has contributed to research in topics: Adsorption & Copolymer. The author has an hindex of 49, co-authored 312 publications receiving 8854 citations. Previous affiliations of Erhan Pişkin include Başkent University.

Nano- and micro-fiber combined scaffolds: a new architecture for bone tissue engineering.

Abstract: One possible interesting way of designing a scaffold for bone tissue engineering is to base it on trying to mimic the biophysical structure of natural extracellular matrix (ECM). This work was developed in order to produce scaffolds for supporting bone cells. Nano and micro fiber combined scaffolds were originally produced from starch based biomaterials by means of a fiber bonding and a electrospinning, two step methodology. The cell culture studies with SaOs-2 human osteoblast-like cell line and rat bone marrow stromal cells demonstrated that presence of nanofibers influenced cell shape and cytoskeletal organization of the cells on the nano/micro combined scaffolds. Moreover, cell viability and Alkaline Phosphatase (ALP) activity for both cell types was found to be higher in nano/micro combined scaffolds than in control scaffolds based on fiber meshes without nanofibers. Consequently, the developed structures are believed have a great potential on the 3D organization and guidance of cells that is provided for engineering of 3-dimensional bone tissues.

In vitro and in vivo degradation of non-woven materials made of poly(ε-caprolactone) nanofibers prepared by electrospinning under different conditions

Abstract: The aim of this study was to prepare non-woven materials from a biodegradable polymer, poly(e-caprolactone) (PCL) by electrospinning. PCL was synthesized by ring-opening polymerization of e-caprola...

In vivo performance of antibiotic embedded electrospun PCL membranes for prevention of abdominal adhesions.

Abstract: The aim of this study was to prepare nonwoven materials from poly(-caprolactone) (PCL) and their antibiotic containing forms by electrospinning, so as to prevent postsurgery induced abdominal adhesions in rats. -Caprolactone was first polymerized by ring-opening polymerization, and then it was processed into matrices composed of nanofibers by electrospinning. A model antibiotic (Biteral®) was embedded within a group of PCL membranes. In the rat model, defects on the abdominal walls in the peritoneum were made to induce adhesion. The plain or antibiotic embedded PCL membranes were implanted on the right side of the abdominal wall. No membrane implantation was made on the left side of the abdominal wall that served as control. Macroscopical and histological evaluations showed that using these barriers reduces the extent, type, and tenacity of adhesion. The antibiotic embedded membranes significantly eliminated postsurgery abdominal adhesions, and also improved healing.

Electrospinning: A Fascinating Method for the Preparation of Ultrathin Fibers

Abstract: Electrospinning is a highly versatile method to process solutions or melts, mainly of polymers, into continuous fibers with diameters ranging from a few micrometers to a few nanometers. This technique is applicable to virtually every soluble or fusible polymer. The polymers can be chemically modified and can also be tailored with additives ranging from simple carbon-black particles to complex species such as enzymes, viruses, and bacteria. Electrospinning appears to be straightforward, but is a rather intricate process that depends on a multitude of molecular, process, and technical parameters. The method provides access to entirely new materials, which may have complex chemical structures. Electrospinning is not only a focus of intense academic investigation; the technique is already being applied in many technological areas.

A Literature Review of Poly(Lactic Acid)

Abstract: A literature review is presented regarding the synthesis, and physicochemical, chemical, and mechanical properties of poly(lactic acid)(PLA). Poly(lactic acid) exists as a polymeric helix, with an orthorhombic unit cell. The tensile properties of PLA can vary widely, depending on whether or not it is annealed or oriented or what its degree of crystallinity is. Also discussed are the effects of processing on PLA. Crystallization and crystallization kinetics of PLA are also investigated. Solution and melt rheology of PLA is also discussed. Four different power-law equations and 14 different Mark–Houwink equations are presented for PLA. Nuclear magnetic resonance, UV–VIS, and FTIR spectroscopy of PLA are briefly discussed. Finally, research conducted on starch–PLA composites is introduced.