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Eric Betzig
Researcher at Howard Hughes Medical Institute
Publications - 151
Citations - 34808
Eric Betzig is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Near-field scanning optical microscope & Microscopy. The author has an hindex of 68, co-authored 145 publications receiving 30551 citations. Previous affiliations of Eric Betzig include University of California, Berkeley & Lawrence Berkeley National Laboratory.
Papers
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Journal ArticleDOI
Imaging intracellular fluorescent proteins at nanometer resolution.
Eric Betzig,George H. Patterson,Rachid Sougrat,O. Wolf Lindwasser,Scott G. Olenych,Juan S. Bonifacino,Michael W. Davidson,Jennifer Lippincott-Schwartz,Harald F. Hess +8 more
TL;DR: This work introduced a method for optically imaging intracellular proteins at nanometer spatial resolution and used this method to image specific target proteins in thin sections of lysosomes and mitochondria and in fixed whole cells to image retroviral protein Gag at the plasma membrane.
Journal ArticleDOI
Near-Field Optics: Microscopy, Spectroscopy, and Surface Modification Beyond the Diffraction Limit
Eric Betzig,Jay K. Trautman +1 more
TL;DR: The near-field optical interaction between a sharp probe and a sample of interest can be exploited to image, spectroscopically probe, or modify surfaces at a resolution inaccessible by traditional far-field techniques, resulting in a technique of considerable versatility.
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Lattice Light Sheet Microscopy: Imaging Molecules to Embryos at High Spatiotemporal Resolution
Bi-Chang Chen,Wesley R. Legant,Kai Wang,Lin Shao,Daniel E. Milkie,Michael W. Davidson,Chris Janetopoulos,Xufeng S. Wu,John A. Hammer,Zhe Liu,Brian P. English,Yuko Mimori-Kiyosue,Daniel P. Romero,Alex T. Ritter,Alex T. Ritter,Jennifer Lippincott-Schwartz,Lillian K. Fritz-Laylin,R. Dyche Mullins,Diana M. Mitchell,Joshua N. Bembenek,Anne-Cécile Reymann,Ralph Böhme,Stephan W. Grill,Jennifer T. Wang,Geraldine Seydoux,U. Serdar Tulu,Daniel P. Kiehart,Eric Betzig +27 more
TL;DR: A new microscope using ultrathin light sheets derived from two-dimensional optical lattices is developed, demonstrating the performance advantages of lattice light-sheet microscopy compared with previous techniques and highlighted phenomena that, when seen at increased spatiotemporal detail, may hint at previously unknown biological mechanisms.
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Breaking the Diffraction Barrier: Optical Microscopy on a Nanometric Scale
TL;DR: A near-field probe has been developed that yields a resolution of ∼12 nm (∼λ/43) and signals ∼104- to 106-fold larger than those reported previously and image contrast is demonstrated to be highly polarization dependent.
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Single molecules observed by near-field scanning optical microscopy.
Eric Betzig,Robert J. Chichester +1 more
TL;DR: Individual carbocyanine dye molecules in a sub-monolayer spread have been imaged with near-field scanning optical microscopy and the orientation of each molecular dipole can be determined to map the electric field distribution in the near- field aperture with molecular spatial resolution.