Eric C. Carnes

TL;DR: P porous nanoparticle-supported lipid bilayers (protocells) that synergistically combine properties of liposomes and nanoporous particles are reported that allow a single protocell loaded with a drug cocktail to kill a drug-resistant HCC cell, representing a 106-fold improvement over comparable liposome.

TL;DR: Recent efforts to develop MSNPs as biocompatible nanocarriers that simultaneously display multiple functions including high visibility/contrast in multiple imaging modalities, dispersibility, binding specificity to a particular target tissue or cell type, ability to load and deliver large concentrations of diverse cargos, and triggered or controlled release of cargo.

TL;DR: The results demonstrate that MS2 VLPs, because of their tolerance of multivalent peptide display and their ability to specifically encapsidate a variety of chemically disparate cargos, induce selective cytotoxicity of cancer in vitro and represent a significant improvement in the characteristics of VLP-based delivery systems.

TL;DR: It is reported that mesoporous silica nanoparticle-supported lipid bilayers (or "protocells") exhibit multiple properties that overcome many of the limitations of existing delivery platforms.

TL;DR: In this paper, a physical system that mimics isolation of a bacterium, such as within an endosome or phagosome during infection, and maintains cell viability under conditions of complete chemical and physical isolation is presented.