Eric Horvitz

Bio: Eric Horvitz is an academic researcher from Microsoft. The author has contributed to research in topics: Context (language use) & User interface. The author has an hindex of 133, co-authored 914 publications receiving 66162 citations. Previous affiliations of Eric Horvitz include Stanford University & Rockwell International.

A Bayesian Approach to Filtering Junk E-Mail

Abstract: In addressing the growing problem of junk E-mail on the Internet, we examine methods for the automated construction of filters to eliminate such unwanted messages from a user’s mail stream. By casting this problem in a decision theoretic framework, we are able to make use of probabilistic learning methods in conjunction with a notion of differential misclassification cost to produce filters Which are especially appropriate for the nuances of this task. While this may appear, at first, to be a straight-forward text classification problem, we show that by considering domain-specific features of this problem in addition to the raw text of E-mail messages, we can produce much more accurate filters. Finally, we show the efficacy of such filters in a real world usage scenario, arguing that this technology is mature enough for deployment.

Predicting Depression via Social Media

Abstract: Major depression constitutes a serious challenge in personal and public health. Tens of millions of people each year suffer from depression and only a fraction receives adequate treatment. We explore the potential to use social media to detect and diagnose major depressive disorder in individuals. We first employ crowdsourcing to compile a set of Twitter users who report being diagnosed with clinical depression, based on a standard psychometric instrument. Through their social media postings over a year preceding the onset of depression, we measure behavioral attributes relating to social engagement, emotion, language and linguistic styles, ego network, and mentions of antidepressant medications. We leverage these behavioral cues, to build a statistical classifier that provides estimates of the risk of depression, before the reported onset. We find that social media contains useful signals for characterizing the onset of depression in individuals, as measured through decrease in social activity, raised negative affect, highly clustered egonetworks, heightened relational and medicinal concerns, and greater expression of religious involvement. We believe our findings and methods may be useful in developing tools for identifying the onset of major depression, for use by healthcare agencies; or on behalf of individuals, enabling those suffering from depression to be more proactive about their mental health.

Principles of mixed-initiative user interfaces

Abstract: Recent debate has centered on the relative promise of focusing user-interface research on developing new metaphors and tools that enhance users abilities to directly manipulate objects versus directing effort toward developing interface agents that provide automation. In this paper, we review principles that show promise for allowing engineers to enhance human-computer interaction through an elegant coupling of automated services with direct manipulation. Key ideas will be highlighted in terms of the Lookout system for scheduling and meeting management.

Personalizing search via automated analysis of interests and activities

Abstract: We formulate and study search algorithms that consider a user's prior interactions with a wide variety of content to personalize that user's current Web search. Rather than relying on the unrealistic assumption that people will precisely specify their intent when searching, we pursue techniques that leverage implicit information about the user's interests. This information is used to re-rank Web search results within a relevance feedback framework. We explore rich models of user interests, built from both search-related information, such as previously issued queries and previously visited Web pages, and other information about the user such as documents and email the user has read and created. Our research suggests that rich representations of the user and the corpus are important for personalization, but that it is possible to approximate these representations and provide efficient client-side algorithms for personalizing search. We show that such personalization algorithms can significantly improve on current Web search.

A diary study of task switching and interruptions

Abstract: We report on a diary study of the activities of information workers aimed at characterizing how people interleave multiple tasks amidst interruptions. The week-long study revealed the type and complexity of activities performed, the nature of the interruptions experienced, and the difficulty of shifting among numerous tasks. We present key findings from the diary study and discuss implications of the findings. Finally, we describe promising directions in the design of software tools for task management, motivated by the findings.

Data Mining: Practical Machine Learning Tools and Techniques

Abstract: Data Mining: Practical Machine Learning Tools and Techniques offers a thorough grounding in machine learning concepts as well as practical advice on applying machine learning tools and techniques in real-world data mining situations. This highly anticipated third edition of the most acclaimed work on data mining and machine learning will teach you everything you need to know about preparing inputs, interpreting outputs, evaluating results, and the algorithmic methods at the heart of successful data mining. Thorough updates reflect the technical changes and modernizations that have taken place in the field since the last edition, including new material on Data Transformations, Ensemble Learning, Massive Data Sets, Multi-instance Learning, plus a new version of the popular Weka machine learning software developed by the authors. Witten, Frank, and Hall include both tried-and-true techniques of today as well as methods at the leading edge of contemporary research. *Provides a thorough grounding in machine learning concepts as well as practical advice on applying the tools and techniques to your data mining projects *Offers concrete tips and techniques for performance improvement that work by transforming the input or output in machine learning methods *Includes downloadable Weka software toolkit, a collection of machine learning algorithms for data mining tasks-in an updated, interactive interface. Algorithms in toolkit cover: data pre-processing, classification, regression, clustering, association rules, visualization

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

Probabilistic Reasoning in Intelligent Systems: Networks of Plausible Inference

Abstract: From the Publisher: Probabilistic Reasoning in Intelligent Systems is a complete andaccessible account of the theoretical foundations and computational methods that underlie plausible reasoning under uncertainty. The author provides a coherent explication of probability as a language for reasoning with partial belief and offers a unifying perspective on other AI approaches to uncertainty, such as the Dempster-Shafer formalism, truth maintenance systems, and nonmonotonic logic. The author distinguishes syntactic and semantic approaches to uncertainty—and offers techniques, based on belief networks, that provide a mechanism for making semantics-based systems operational. Specifically, network-propagation techniques serve as a mechanism for combining the theoretical coherence of probability theory with modern demands of reasoning-systems technology: modular declarative inputs, conceptually meaningful inferences, and parallel distributed computation. Application areas include diagnosis, forecasting, image interpretation, multi-sensor fusion, decision support systems, plan recognition, planning, speech recognition—in short, almost every task requiring that conclusions be drawn from uncertain clues and incomplete information. Probabilistic Reasoning in Intelligent Systems will be of special interest to scholars and researchers in AI, decision theory, statistics, logic, philosophy, cognitive psychology, and the management sciences. Professionals in the areas of knowledge-based systems, operations research, engineering, and statistics will find theoretical and computational tools of immediate practical use. The book can also be used as an excellent text for graduate-level courses in AI, operations research, or applied probability.

Machine learning

Abstract: Machine Learning is the study of methods for programming computers to learn. Computers are applied to a wide range of tasks, and for most of these it is relatively easy for programmers to design and implement the necessary software. However, there are many tasks for which this is difficult or impossible. These can be divided into four general categories. First, there are problems for which there exist no human experts. For example, in modern automated manufacturing facilities, there is a need to predict machine failures before they occur by analyzing sensor readings. Because the machines are new, there are no human experts who can be interviewed by a programmer to provide the knowledge necessary to build a computer system. A machine learning system can study recorded data and subsequent machine failures and learn prediction rules. Second, there are problems where human experts exist, but where they are unable to explain their expertise. This is the case in many perceptual tasks, such as speech recognition, hand-writing recognition, and natural language understanding. Virtually all humans exhibit expert-level abilities on these tasks, but none of them can describe the detailed steps that they follow as they perform them. Fortunately, humans can provide machines with examples of the inputs and correct outputs for these tasks, so machine learning algorithms can learn to map the inputs to the outputs. Third, there are problems where phenomena are changing rapidly. In finance, for example, people would like to predict the future behavior of the stock market, of consumer purchases, or of exchange rates. These behaviors change frequently, so that even if a programmer could construct a good predictive computer program, it would need to be rewritten frequently. A learning program can relieve the programmer of this burden by constantly modifying and tuning a set of learned prediction rules. Fourth, there are applications that need to be customized for each computer user separately. Consider, for example, a program to filter unwanted electronic mail messages. Different users will need different filters. It is unreasonable to expect each user to program his or her own rules, and it is infeasible to provide every user with a software engineer to keep the rules up-to-date. A machine learning system can learn which mail messages the user rejects and maintain the filtering rules automatically. Machine learning addresses many of the same research questions as the fields of statistics, data mining, and psychology, but with differences of emphasis. Statistics focuses on understanding the phenomena that have generated the data, often with the goal of testing different hypotheses about those phenomena. Data mining seeks to find patterns in the data that are understandable by people. Psychological studies of human learning aspire to understand the mechanisms underlying the various learning behaviors exhibited by people (concept learning, skill acquisition, strategy change, etc.).