E
Eric J. Topol
Researcher at Scripps Health
Publications - 1406
Citations - 162373
Eric J. Topol is an academic researcher from Scripps Health. The author has contributed to research in topics: Myocardial infarction & Angioplasty. The author has an hindex of 193, co-authored 1373 publications receiving 151025 citations. Previous affiliations of Eric J. Topol include Loyola University Chicago & Cleveland Clinic.
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Journal ArticleDOI
Influence of diabetes mellitus on clinical outcomes across the spectrum of acute coronary syndromes. Findings from the GUSTO-IIb Study
Darren K. McGuire,H. Emanuelsson,Christopher B. Granger,E. Magnus Ohman,David J. Moliterno,Harvey D. White,Diego Ardissino,James W. Box,Robert M. Califf,Eric J. Topol +9 more
TL;DR: The statistically non-significant trend toward improved outcomes with hirudin was similar among patients with and without diabetes, with a greater point estimate for the absolute difference in patients with diabetes.
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Genetic susceptibility to myocardial infarction and coronary artery disease
TL;DR: Four principal and interdependent processes--lipoprotein handling, endothelial integrity, arterial inflammation, arterIAL inflammation, and thrombosis--have been supported as important via the clustering of genes, thus far implicated in CAD susceptibility.
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Strategies to achieve coronary arterial plaque stabilization.
Ramin Rabbani,Eric J. Topol +1 more
TL;DR: Evidence supporting plaque stabilization by Matrix metalloproteinase inhibitors as well as macrolide antibiotics and gene therapy approaches show promise in achieving plaque stabilization is discussed in detail in this review.
Journal ArticleDOI
A multicenter, randomized, placebo-controlled trial of a new form of intravenous recombinant tissue-type plasminogen activator (activase) in acute myocardial infarction.
Eric J. Topol,Douglas C. Morris,Richard W. Smalling,Richard R. Schumacher,Charles R. Taylor,Akira Nishikawa,Henry A. Liberman,Desire Collen,Margaret E. Tufte,Elliott B. Grossbard,William W. O'Neill +10 more
TL;DR: This tissue plasminogen activator preparation achieves a high rate of recanalization and, at the doses employed, exhibits increased fibrinogen sparing compared with intracoronary streptokinase.
Journal ArticleDOI
Whole-Genome Sequencing of a Healthy Aging Cohort
Galina Erikson,Dale L. Bodian,Manuel Rueda,Bhuvan Molparia,Erick R. Scott,Ashley A. Scott-Van Zeeland,Sarah E. Topol,Nathan E. Wineinger,John E. Niederhuber,John E. Niederhuber,Eric J. Topol,Ali Torkamani +11 more
TL;DR: The results suggest healthy aging is an overlapping but distinct phenotype from exceptional longevity that may be enriched with disease-protective genetic factors, and suggests protection against cognitive decline is a genetic component of healthy aging.