E
Eric J. Topol
Researcher at Scripps Health
Publications - 1406
Citations - 162373
Eric J. Topol is an academic researcher from Scripps Health. The author has contributed to research in topics: Myocardial infarction & Angioplasty. The author has an hindex of 193, co-authored 1373 publications receiving 151025 citations. Previous affiliations of Eric J. Topol include Loyola University Chicago & Cleveland Clinic.
Papers
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Journal ArticleDOI
The personal and clinical utility of polygenic risk scores.
TL;DR: The authors review recent studies that have demonstrated the utility of polygenic risk scores for disease risk stratification and their potential impact on early disease detection, prevention, therapeutic intervention and life planning.
Book
Textbook of Cardiovascular Medicine
TL;DR: This volume covers aspects of cardiology from molecular genetics, to preventive cardiology, to state-of-the-art interventional cardiology techniques, to healthcare policy trends that affect cardiovascular medicine.
Journal ArticleDOI
A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease.
TL;DR: This study demonstrates the natural history of aspirin resistance in a stable population, documenting a greater than threefold increase in the risk of major adverse events associated with aspirin resistance.
Journal ArticleDOI
Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes.
Sunil V. Rao,James G. Jollis,Robert A. Harrington,Christopher B. Granger,L. Kristin Newby,Paul W. Armstrong,David J. Moliterno,Lauren Lindblad,Karen S. Pieper,Eric J. Topol,Jonathan S. Stamler,Robert M. Califf +11 more
TL;DR: Blood transfusion in the setting of acute coronary syndromes is associated with higher mortality, and this relationship persists after adjustment for other predictive factors and timing of events.
Journal ArticleDOI
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke
Anna Helgadottir,Andrei Manolescu,Gudmar Thorleifsson,Solveig Gretarsdottir,Helga Jonsdottir,Unnur Thorsteinsdottir,Nilesh J. Samani,Gudmundur Gudmundsson,Struan F.A. Grant,Gudmundur Thorgeirsson,Sigurlaug Sveinbjörnsdóttir,Einar M. Valdimarsson,Stefan E Matthiasson,Halldor Johannsson,Olof Gudmundsdottir,Mark E. Gurney,Jesus Sainz,Margret Thorhallsdottir,Margret B. Andresdottir,Michael L. Frigge,Eric J. Topol,Augustine Kong,Vilmundur Gudnason,Hakon Hakonarson,Jeffrey R. Gulcher,Kari Stefansson +25 more
TL;DR: It is concluded that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall.