E
Eric J. Wagner
Researcher at University of Texas Medical Branch
Publications - 129
Citations - 8213
Eric J. Wagner is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Polyadenylation & Gene. The author has an hindex of 36, co-authored 111 publications receiving 6870 citations. Previous affiliations of Eric J. Wagner include Duke University & University of North Carolina at Chapel Hill.
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Both Natural and Designed Micro RNAs Can Inhibit the Expression of Cognate mRNAs When Expressed in Human Cells
TL;DR: It is shown that the human mir-30 miRNA can be excised from irrelevant, endogenously transcribed mRNAs encompassing the predicted 71 nucleotide mir- 30 precursor.
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Understanding the language of Lys36 methylation at histone H3
TL;DR: Although H3K36 methylation is most commonly associated with the transcription of active euchromatin, it has also been implicated in diverse processes, including alternative splicing, dosage compensation and transcriptional repression, as well as DNA repair and recombination.
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Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail
TL;DR: Results suggest that the coordinated synthesis of replication- dependent and variant histone mRNAs is achieved by signals that affect formation of the 3′ end of the replication-dependent histonemRNAs.
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Autoregulation of Polypyrimidine Tract Binding Protein by Alternative Splicing Leading to Nonsense-Mediated Decay
Matthew C Wollerton,Clare Gooding,Eric J. Wagner,Mariano A. Garcia-Blanco,Christopher W.J. Smith +4 more
TL;DR: It is shown that alternative skipping of PTB exon 11 leads to an mRNA that is removed by NMD and that this pathway consumes at least 20% of the PTB mRNA in HeLa cells, indicating a high prevalence of human alternative splicing leading to NMD.
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Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types.
Zheng Xia,Lawrence A. Donehower,Thomas A. Cooper,Joel R. Neilson,David A. Wheeler,Eric J. Wagner,Wei Li +6 more
TL;DR: A novel bioinformatics algorithm (DaPars) is developed for the de novo identification of dynamic APAs from standard RNA-seq that implicate CstF64, an essential polyadenylation factor, as a master regulator of 3'-UTR shortening across multiple tumour types.