E
Eric M. Gale
Researcher at Harvard University
Publications - 42
Citations - 2217
Eric M. Gale is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & MRI contrast agent. The author has an hindex of 22, co-authored 33 publications receiving 1433 citations. Previous affiliations of Eric M. Gale include University of Georgia.
Papers
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Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers
TL;DR: This comprehensive review describes the state of the art of clinically approved contrast agents, their mechanism of action, and factors influencing their safety and efforts to make safer contrast agents either by increasing relaxivity, increasing resistance to metal ion release, or by moving to gadolinium(III)-free alternatives.
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A Manganese Alternative to Gadolinium for MRI Contrast.
TL;DR: Mn-FBP provided equivalent thrombus enhancement to the state of the art Gd analogue, EP-2104R, in a rat model of arterial thrombosis and is a lead development candidate for an imaging probe that is compatible with renally compromised patients.
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MR imaging probes: design and applications
TL;DR: This perspective outlines strategies towards the development of MR imaging probes and methods to enhance the signal generating capacity of MR probes and how to achieve tissue specificity through protein targeting or probe activation within the tissue microenvironment.
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Molecular Magnetic Resonance Imaging Using a Redox-Active Iron Complex
Huan Wang,Veronica Clavijo Jordan,Ian Ramsay,Mozhdeh Sojoodi,Bryan C. Fuchs,Kenneth K. Tanabe,Peter Caravan,Eric M. Gale +7 more
TL;DR: Significant signal enhancement of the inflamed pancreas correlates strongly and significantly with ex vivo quantitation of the pro-inflammatory biomarker myeloperoxidase, the first example of using metal ion redox for the MR imaging of pathologic change in vivo.
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A Manganese-based Alternative to Gadolinium: Contrast-enhanced MR Angiography, Excretion, Pharmacokinetics, and Metabolism.
TL;DR: Mn-PyC3A enables contrast-enhanced MR angiography with comparable contrast enhancement to gadolinium-based agents and may overcome concerns regarding gadolinia-associated toxicity and retention.