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Eric Marthinet
Researcher at University of Geneva
Publications - 3
Citations - 146
Eric Marthinet is an academic researcher from University of Geneva. The author has contributed to research in topics: Regulation of gene expression & Proglucagon. The author has an hindex of 3, co-authored 3 publications receiving 140 citations. Previous affiliations of Eric Marthinet include Boston Children's Hospital.
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Journal ArticleDOI
Pax6 Controls the Expression of Critical Genes Involved in Pancreatic α Cell Differentiation and Function
Yvan Gosmain,Eric Marthinet,Claire Cheyssac,Audrey Guérardel,Aline Mamin,Liora S. Katz,Karim Bouzakri,Jacques Philippe +7 more
TL;DR: It is concluded that Pax6 is critical for α cell function and differentiation through the transcriptional control of key genes involved in glucagon gene transcription, proglucagon processing, and α cell differentiation.
Journal ArticleDOI
Severe congenital hyperinsulinism caused by a mutation in the Kir6.2 subunit of the adenosine triphosphate-sensitive potassium channel impairing trafficking and function.
Eric Marthinet,Alain Bloc,Yoshimoto Oka,Yukio Tanizawa,Bernhard Wehrle-Haller,Victor Bancila,Jean-Michel Marie Maurice Dubuis,Jacques Philippe,Valerie M. Schwitzgebel +8 more
TL;DR: The H259R mutation of the Kir6.2 subunit results in a channel that is partially retained in the ER and nonfunctional upon arrival at the plasma membrane, a disease presenting with severe hypoglycemia in the newborn period.
Journal ArticleDOI
Pax6 regulates the proglucagon processing enzyme PC2 and its chaperone 7B2.
TL;DR: It is concluded that Pax6 is critical for glucagon biosynthesis and processing by directly and indirectly activating the glucagon gene through cMaf and Beta2/NeuroD1, as well as the PC2 and 7B2 genes.