Author
Eric McElory
Bio: Eric McElory is an academic researcher from Pfizer. The author has contributed to research in topics: One-pot synthesis. The author has an hindex of 1, co-authored 2 publications receiving 125 citations.
Topics: One-pot synthesis
Papers
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TL;DR: In this article, a microwave-promoted one-pot, two-step reaction sequence combining anthranilic acids, carboxylic acids, and amines was proposed for 2,3-disubstituted 3 H -quinazolin-4-ones.
130 citations
TL;DR: In this article, a microwave-promoted one-pot, two-step reaction sequence combining anthranilic acids, carboxylic acids, and amines was proposed for 2,3-disubstituted 3 H -quinazolin-4-ones.
Abstract: A practical synthesis of 2,3-disubstituted 3 H -quinazolin-4-ones 1 with broad chemistry scope is described. The key step is the microwave promoted one-pot, two-step reaction sequence combining anthranilic acids, carboxylic acids, and amines providing efficient access to this important class of heterocycles.
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TL;DR: A concise account of the isolation, bioactivity, and synthesis of bioactive quinazolinone-based natural products for the period 1983-2005 is given in this paper.
607 citations
TL;DR: In this review, more than 220 published examples of microwave-assisted synthetic organic transformations from the 2004 to 2008 literature are discussed and more than 500 reaction schemes are presented in the Electronic Supplementary Material.
Abstract: Direct and rapid heating by microwave irradiation in combination with sealed vessel processing in many cases enables reactions to be carried out in a fraction of the time generally required using conventional conditions. This makes microwave chemistry an ideal tool for rapid reaction scouting and optimization of conditions, allowing very rapid progress through hypotheses–experiment–results iterations. The speed at which multiple variations of reaction conditions can be performed allows a morning discussion of “What should we try?” to become an after-lunch discussion of “What were the results” Not surprisingly, therefore, many scientists both in academia and industry have turned to microwave synthesis as a front-line methodology for their projects. In this review, more than 220 published examples of microwave-assisted synthetic organic transformations from the 2004 to 2008 literature are discussed. An additional ca. 500 reaction schemes are presented in the Electronic Supplementary Material, providing the reader with an overall number of ca. 930 references in this fast-moving and exciting field.
423 citations
TL;DR: A series of 2-methylaminobenzimidazole derivatives (1-11) synthesized by the reaction of 2-(chloromethyl)-1H-benzimidzole derivatives with primary aromatic amines showed good analgesic and anti-inflammatory activities.
285 citations
TL;DR: KAl(SO4)2·12H2O was found to catalyze efficiently a one-pot three-component cyclocondensation of isatoic anhydride and primary amines or ammonia sources such as NH4 2CO3, NH4OAc and NH4Cl with aromatic aldehydes under mild conditions to afford the corresponding mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-ones in good yields as mentioned in this paper.
181 citations
TL;DR: The current review article will briefly outline the new routes and strategies for the synthesis of valuable 4(3H)-quinazolinones.
Abstract: The 4(3H)-quinazolinone is a frequently encountered heterocycle with broad applications including antimalarial, antitumor, anticonvulsant, fungicidal, antimicrobial, and anti-inflammatory. The current review article will briefly outline the new routes and strategies for the synthesis of valuable 4(3H)-quinazolinones.
176 citations