E
Erica Barini
Researcher at University of Dundee
Publications - 5
Citations - 540
Erica Barini is an academic researcher from University of Dundee. The author has contributed to research in topics: PINK1 & Parkin. The author has an hindex of 3, co-authored 5 publications receiving 363 citations.
Papers
More filters
Journal ArticleDOI
Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand.
Thomas G. McWilliams,Alan R. Prescott,Lambert Montava-Garriga,Graeme Ball,François Singh,Erica Barini,Miratul M. K. Muqit,Simon Philip Brooks,Ian G. Ganley +8 more
TL;DR: These findings provide the first in vivo evidence that Pink1 is detectable at basal levels and that basal mammalian mitophagy occurs independently of PINK1, and suggest multiple, yet-to-be-discovered pathways orchestrating mammalian mitochondrial integrity in a context-dependent fashion.
Journal ArticleDOI
Phosphorylation of Parkin at serine 65 is essential for its activation in vivo.
Thomas G. McWilliams,Thomas G. McWilliams,Erica Barini,Risto Pohjolan-Pirhonen,Simon Philip Brooks,François Singh,Sophie Burel,Kristin Balk,Atul Kumar,Lambert Montava-Garriga,Alan R. Prescott,Sidi Mohamed Hassoun,François Mouton-Liger,Graeme Ball,Rachel Hills,Axel Knebel,Ayse Ulusoy,Donato A. Di Monte,Jevgenia Tamjar,Odetta Antico,Kyle Fears,Laura Smith,Riccardo Brambilla,Eino Palin,Miko Valori,Johanna Eerola-Rautio,Pentti J. Tienari,Olga Corti,Stephen B. Dunnett,Ian G. Ganley,Anu Suomalainen,Miratul M. K. Muqit +31 more
TL;DR: The clinical relevance of the findings is substantiated by the discovery of homozygous PARKIN (PARK2) p.S65N mutations in two unrelated patients with PD and biochemical and structural analysis demonstrates that the ParkinS 65N/S65n mutant is pathogenic and cannot be activated by PINK1.
Journal ArticleDOI
The anthelmintic drug niclosamide and its analogues activate the Parkinson's Disease associated protein kinase PINK1
Erica Barini,Ageo Miccoli,Federico Tinarelli,Katie Mulholland,Hachemi Kadri,Farhat L. Khanim,Laste Stojanovski,Kevin D. Read,Kerry A. Burness,J. Julian Blow,Youcef Mehellou,Miratul M. K. Muqit +11 more
TL;DR: It is shown that the anthelmintic drug niclosamide and its analogues are capable of activating PINK1 in cells through the reversible impairment of the mitochondrial membrane potential.
Journal ArticleDOI
Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1.
Odetta Antico,Alban Ordureau,Michael Stevens,François Singh,Raja Sekhar Nirujogi,Marek Gierlinski,Erica Barini,Mollie L. Rickwood,Alan R. Prescott,Rachel Toth,Ian G. Ganley,J. Wade Harper,Miratul M. K. Muqit +12 more
TL;DR: In this paper, a proteomic analysis of mitochondria from mouse neurons was performed to identify ubiquitylated substrates of endogenous Parkin, and the results revealed a subset of 49 PINK1 activation-dependent diGLY sites.
Posted ContentDOI
Global ubiquitylation analysis of mitochondria in primary neurons identifies physiological Parkin targets following activation of PINK1
Odetta Antico,Alban Ordureau,Michael Stevens,François Singh,Marek Gierlinski,Erica Barini,Mollie L. Rickwood,Alan R. Prescott,Rachel Toth,Ian G. Ganley,J. Wade Harper,Miratul M. K. Muqit +11 more
TL;DR: In this article, a global proteomic analysis of mitochondria from mouse neurons was performed to identify ubiquitylated substrates of endogenous Parkin activation, and the results indicated that Parkin-dependent diGLY sites may represent robust biomarkers for PINK1 and Parkin activity in vivo.