Author
Erich Sackmann
Other affiliations: Ludwig Maximilian University of Munich, University of Ljubljana, University of Ulm
Bio: Erich Sackmann is an academic researcher from Technische Universität München. The author has contributed to research in topics: Vesicle & Lipid bilayer. The author has an hindex of 75, co-authored 259 publications receiving 19716 citations. Previous affiliations of Erich Sackmann include Ludwig Maximilian University of Munich & University of Ljubljana.
Topics: Vesicle, Lipid bilayer, Membrane, Bilayer, Monolayer
Papers published on a yearly basis
Papers
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TL;DR: This work focuses on lipid-bilayer membranes supported on solid substrates, which are widely used as cell-surface models that connect biological and artificial materials and when these systems are coupled with advanced semiconductor technology.
Abstract: Lipid-bilayer membranes supported on solid substrates are widely used as cell-surface models that connect biological and artificial materials. They can be placed either directly on solids or on ultrathin polymer supports that mimic the generic role of the extracellular matrix. The tools of modern genetic engineering and bioorganic chemistry make it possible to couple many types of biomolecule to supported membranes. This results in sophisticated interfaces that can be used to control, organize and study the properties and function of membranes and membrane-associated proteins. Particularly exciting opportunities arise when these systems are coupled with advanced semiconductor technology.
887 citations
TL;DR: The viscoelastic properties of the cytoplasm of J774 macrophages are measured with a recently developed microrheometer and the magnetophoretic motion of the ferromagnetic beads at a constant magnetic force is analyzed, suggesting that the cy toplasm is composed of clusters of densely packed and cross-linked filaments separated by soft regions.
760 citations
TL;DR: A magnetic bead microrheometer has been designed which allows the generation of forces up to 10(4) pN on 4.5 micron paramagnetic beads to measure local viscoelastic properties of the surface of adhering fibroblasts and a surface shear modulus of mu * is found.
722 citations
TL;DR: In this paper, the authors used the film balance technique at different stages of ionization at pressures above the lateral vapour pressure to measure the lateral compressibility and thermal expansion coefficient of synthetic lecithins and phosphatidic acid.
Abstract: 2014 Monolayers of synthetic lecithins as well as phosphatidic acid at different stages of ionization were studied with the film balance technique at pressures above the lateral vapour pressure. Pressure (03C0) versus area (a) curves (isotherms) and, by application of a special technique, area (a) versus temperature (T) curves (isobars) were recorded. From these data, plots of the lateral compressibility, ~, as a function of lateral lipid density (a-1) and of the thermal expansion coefficient, 03B1, as a function of temperature (T) were obtained. The well known transition (at T = TM) between the expanded (fluid) and the condensed (crystalline) states of the films, called the main transition, is characterized by a non-horizontal deflection of the isotherms (and isobars) in the coexistence region. A pronounced hysteresis shows that it is a first order transition. Two additional phase transitions, one at T > TM (fluid region) and one at T TM (crystalline region), were revealed by breaks in the slopes of the isotherms and the isobars. Discontinuities in the compressibilities and in the expansion coefficients show that these transitions are of second order. A flow experiment showed : that the fluid ~ fluid transition is also characterized by a pronounced discontinuity in viscosity. In fatty acid monolayers the transition (at T TM) between two crystalline states is of weak first order ( 2014 10 J./Mole). LE JOURNAL DE PHYSIQUE TOME 39, MARS 1978,
530 citations
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28 Jul 2005
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。
18,940 citations
5,284 citations
TL;DR: The atomic force microscope (AFM) is not only used to image the topography of solid surfaces at high resolution but also to measure force-versus-distance curves as discussed by the authors, which provide valuable information on local material properties such as elasticity, hardness, Hamaker constant, adhesion and surface charge densities.
3,281 citations
TL;DR: In this paper, pH-induced self-assembly of a peptide-amphiphile was used to make a nanostructured fibrous scaffold reminiscent of extracellular matrix.
Abstract: We have used the pH-induced self-assembly of a peptide-amphiphile to make a nanostructured fibrous scaffold reminiscent of extracellular matrix. The design of this peptide-amphiphile allows the nanofibers to be reversibly cross-linked to enhance or decrease their structural integrity. After cross-linking, the fibers are able to direct mineralization of hydroxyapatite to form a composite material in which the crystallographic c axes of hydroxyapatite are aligned with the long axes of the fibers. This alignment is the same as that observed between collagen fibrils and hydroxyapatite crystals in bone.
3,125 citations
TL;DR: The physical principles underlying some current biomedical applications of magnetic nanoparticles are reviewed and the relevant physics of magnetic materials and their responses to applied magnetic fields are surveyed.
Abstract: The physical principles underlying some current biomedical applications of magnetic nanoparticles are reviewed. Starting from well-known basic concepts, and drawing on examples from biology and biomedicine, the relevant physics of magnetic materials and their responses to applied magnetic fields are surveyed. The way these properties are controlled and used is illustrated with reference to (i) magnetic separation of labelled cells and other biological entities; (ii) therapeutic drug, gene and radionuclide delivery; (iii) radio frequency methods for the catabolism of tumours via hyperthermia; and (iv) contrast enhancement agents for magnetic resonance imaging applications. Future prospects are also discussed.
2,815 citations