Erik Laurini

TL;DR: The targeted system had enhanced siRNA delivery, stronger gene silencing, and more potent anticancer activity compared to nontargeted or covalent dendrimer-based systems, and can be further developed to provide RNAi-based personalized medicine against cancer.

TL;DR: Targeting this pathway with vismodegib, a novel SMO inhibitor, results in impressive tumor regression in patients harboring genetic defects in this pathway, however, a secondary mutation in SMO has been reported in medulloblastoma patients following relapse on vismODEgib to date.

TL;DR: The low generation dendrimer G(5) in combination with sticky siRNA therapeutics may constitute a promising gene silencing-based approach for combating castration-resistant prostate tumors or other cancers and diseases, for which no effective treatment currently exists.

TL;DR: In this paper, the authors investigate oil/water emulsions through interfacial tension using two common non-ionic surfactants, Tween 80 and Span 20, in the concentration range C (0.3 − 1 wt%) well above their respective CMCs.

TL;DR: This study presents for the first time the 3D model of the σ1 receptor protein as obtained from homology modeling techniques, shows the applicability of this structure to docking-based virtual screening, and defines a computational strategy to optimize the results based on a combination of 3D pharmacophore-based docking and MM/PBSA free energy of binding scoring.