E
Erik M. Ullian
Researcher at University of California, San Francisco
Publications - 68
Citations - 8852
Erik M. Ullian is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Astrocyte & Synaptogenesis. The author has an hindex of 37, co-authored 59 publications receiving 7593 citations. Previous affiliations of Erik M. Ullian include Cleveland Clinic & University of California, Berkeley.
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Journal ArticleDOI
Thrombospondins Are Astrocyte-Secreted Proteins that Promote CNS Synaptogenesis
Karen S. Christopherson,Erik M. Ullian,Caleb C.A. Stokes,Christine E. Mullowney,Johannes W. Hell,Azin Agah,Jack Lawler,Deane F. Mosher,Paul Bornstein,Ben A. Barres +9 more
TL;DR: These studies identify TSPs as CNS synaptogenic proteins, provide evidence that astrocytes are important contributors to synaptogenesis within the developing CNS, and suggest that TSP-1 and -2 act as a permissive switch that times CNSsynaptogenesis by enabling neuronal molecules to assemble into synapses within a specific window of CNS development.
Journal ArticleDOI
Control of synapse number by glia.
TL;DR: It is shown that few synapses form in the absence of glial cells and that the fewsynapses that do form are functionally immature, and that CNS synapse number can be profoundly regulated by nonneuronal signals.
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Astrocytes and disease: a neurodevelopmental perspective
Anna V. Molofsky,Robert Krenick,Erik M. Ullian,Hui-Hsin Tsai,Benjamin Deneen,William D. Richardson,Ben A. Barres,David H. Rowitch +7 more
TL;DR: It is proposed here that a precise understanding of astrocyte development is critical to defining heterogeneity and could lead advances in understanding and treating a variety of neuropsychiatric diseases.
Journal ArticleDOI
Conditional Loss of Dicer Disrupts Cellular and Tissue Morphogenesis in the Cortex and Hippocampus
Tigwa H. Davis,Trinna L. Cuellar,Selina M. Koch,Allison J. Barker,Brian D. Harfe,Michael T. McManus,Erik M. Ullian +6 more
TL;DR: In vivo studies of Dicer and miRNAs provide additional support for previous in vitro studies indicating that misregulation of this pathway may result in gross abnormalities in cell number and function that may contribute to a variety of neurological disorders.
Journal ArticleDOI
Zika virus cell tropism in the developing human brain and inhibition by azithromycin
Hanna Retallack,Elizabeth Di Lullo,Carolina Arias,Kristeene A. Knopp,Matthew T. Laurie,Carmen Sandoval-Espinosa,Walter R Mancia Leon,Robert Krencik,Robert Krencik,Erik M. Ullian,Julien Spatazza,Alex A. Pollen,Caleigh Mandel-Brehm,Tomasz J. Nowakowski,Arnold R. Kriegstein,Joseph L. DeRisi +15 more
TL;DR: The characterization of infection in the developing human brain clarifies the pathogenesis of congenital ZIKV infection and provides the basis for investigating possible therapeutic strategies to safely alleviate or prevent the most severe consequences of the epidemic.