E
Erin J. van Schaik
Researcher at Texas A&M Health Science Center College of Medicine
Publications - 27
Citations - 840
Erin J. van Schaik is an academic researcher from Texas A&M Health Science Center College of Medicine. The author has contributed to research in topics: Coxiella burnetii & Q fever. The author has an hindex of 11, co-authored 21 publications receiving 726 citations. Previous affiliations of Erin J. van Schaik include University of Colorado Boulder & Texas A&M University System.
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Journal ArticleDOI
Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii
TL;DR: The Dot/Icm (defect in organelle trafficking/intracellular multiplication) system is described, which is used by C. burnetii to secrete a range of effector proteins into the host cell, and the role of these effectors in remodelling thehost cell is discussed.
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The Pseudomonas aeruginosa type IV pilin receptor binding domain functions as an adhesin for both biotic and abiotic surfaces
Carmen L. Giltner,Erin J. van Schaik,Gerald F. Audette,Dan Kao,Robert S. Hodges,Daniel J. Hassett,Randall T. Irvin +6 more
TL;DR: The C‐terminal receptor binding domain appears to have evolved for binding a variety of surfaces, including stainless steel and other abiotic surfaces, during the initial stages of biofilm formation.
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DNA Binding: a Novel Function of Pseudomonas aeruginosa Type IV Pili
Erin J. van Schaik,Carmen L. Giltner,Gerald F. Audette,David W. Keizer,Daisy L. Bautista,Carolyn M. Slupsky,Brian D. Sykes,Randall T. Irvin +7 more
TL;DR: The conservation of a Thr residue in all type IV pilin monomers examined to date, along with electrostatic data, implies that DNA binding is a conserved function of type IV pili, which could be important for biofilm formation both in vivo during an infection and ex vivo on abiotic surfaces.
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Burkholderia pseudomallei Isocitrate Lyase Is a Persistence Factor in Pulmonary Melioidosis: Implications for the Development of Isocitrate Lyase Inhibitors as Novel Antimicrobials
TL;DR: Results suggest that the inhibition of isocitrate lyase activity does not necessarily attenuate virulence as previously observed for Mycobacterium tuberculosis infections but does force the bacteria into a replicating state where antibiotics are effective.
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DNA-Binding Protein Nanotubes: Learning from Nature's Nanotech Examples
TL;DR: Like type IV pili, the controlled assembly of protein nanotubes from an engineered Pseudomonas aeruginosa type IV pilin monomer binds DNA, further broadening their appeal in nanotechnological applications.