E
Erkki Ruoslahti
Researcher at Discovery Institute
Publications - 603
Citations - 105129
Erkki Ruoslahti is an academic researcher from Discovery Institute. The author has contributed to research in topics: Fibronectin & Integrin. The author has an hindex of 159, co-authored 600 publications receiving 101072 citations. Previous affiliations of Erkki Ruoslahti include University of Helsinki & University of California.
Papers
More filters
Journal ArticleDOI
New perspectives in cell adhesion : RGD and integrins
TL;DR: Together, the adhesion proteins and their receptors constitute a versatile recognition system providing cells with anchorage, traction for migration, and signals for polarity, position, differentiation, and possibly growth.
Journal ArticleDOI
Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule
TL;DR: The ability of fibronectin to bind cells can be accounted for by the tetrapeptide L-arginyl-glycyl- L-aspartyl-L-serine, a sequence which is part of the cell attachment domain of fibronsectin and present in at least five other proteins.
Journal ArticleDOI
RGD and other recognition sequences for integrins.
TL;DR: As the integrin-mediated cell attachment influences and regulates cell migration, growth, differentiation, and apoptosis, the RGD peptides and mimics can be used to probe integrin functions in various biological systems.
Journal ArticleDOI
Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model
TL;DR: In vivo selection of phage display libraries was used to isolate peptides that home specifically to tumor blood vessels that enhanced the efficacy of the anticancer drug doxorubicin and reduced its toxicity.
Journal ArticleDOI
Binding of soluble form of fibroblast surface protein, fibronectin, to collagen.
Eva Engvall,Erkki Ruoslahti +1 more
TL;DR: The findings suggest the possibility that Malignantly transformed fibroblasts lack surface fibronectin, which results in a lack of anchorage to the surrounding intercellular matrix, which could contribute to the malignant growth behavior.