E
Ernest Martinez
Researcher at University of California, Riverside
Publications - 44
Citations - 4203
Ernest Martinez is an academic researcher from University of California, Riverside. The author has contributed to research in topics: Transcription factor II D & General transcription factor. The author has an hindex of 26, co-authored 44 publications receiving 3987 citations. Previous affiliations of Ernest Martinez include University of Lausanne & Rockefeller University.
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Journal ArticleDOI
Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo
Ernest Martinez,Vikas B. Palhan,Agneta Tjernberg,Elena S. Lymar,Armin M. Gamper,Tapas K. Kundu,Brian T. Chait,Robert G. Roeder +7 more
TL;DR: The results suggest cellular roles of STAGA in chromatin modification, transcription, and transcription-coupled processes through direct physical interactions with sequence-specific transcription activators and with components of the splicing and DNA repair machineries.
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Prevalence of the initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA-less core promoters.
TL;DR: Genome-scale computational analyses indicate that approximately 76% of human core promoters lack TATA-like elements, have a high GC content, and are enriched in Sp1-binding sites, and point to novel vertebrate-specific DNA motifs that might play a selective role in Tata-independent transcription.
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A Novel Human SRB/MED-Containing Cofactor Complex, SMCC, Involved in Transcription Regulation
Wei Gu,Sohail Malik,Mitsuhiro Ito,Chao-Xing Yuan,Joseph D. Fondell,Xiaolong Zhang,Ernest Martinez,Jun Qin,Robert G. Roeder +8 more
TL;DR: Both positive and negative functional capabilities for the human complex are demonstrated, the complex shows direct activator interactions but, unlike yeast mediator, can act independently of the RNA polymerase II CTD.
Journal ArticleDOI
Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression.
Walter Wahli,Ernest Martinez +1 more
TL;DR: The similarity between all these hormone response enhancer elements, as well as between the receptors themselves, indicates a conserved general strategy for the hormonal control of transcription by steroids.
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The estrogen-responsive element as an inducible enhancer: DNA sequence requirements and conversion to a glucocorticoid-responsive element.
TL;DR: The estrogen‐ responsive element (ERE) present in the 5′‐flanking region of the Xenopus laevis vitellogenin (vit) gene B1 has been characterized by transient expression analysis of chimeric vit‐tk‐CAT (chloramphenicol acetyltransferase) gene constructs transfected into the human estrogen‐responsive MCF‐7 cell line.