Erno Vreugdenhil

TL;DR: The balance in actions mediated by the two corticosteroid receptor types in these neurons appears critical for neuronal excitability, stress responsiveness, and behavioral adaptation and Dysregulation of this MR/GR balance brings neurons in a vulnerable state with consequences for regulation of the stress response and enhanced vulnerability to disease in genetically predisposed individuals.

TL;DR: It is concluded that deep sequencing provides a major advance in robustness, comparability and richness of expression profiling data and is expected to boost collaborative, comparative and integrative genomics studies.

TL;DR: A transient, dose-dependent decrease in BDNF mRNA and protein in the hippocampus is found, which may underly changes in neuronal plasticity in the hippocampal subfields after short-term changes in corticosterone concentrations.

TL;DR: The findings show an association between RA and a previously unreported polymorphism in the hGR gene that increased stability of hGRbeta mRNA, which could contribute to an altered glucocorticoid sensitivity since the h GRbeta is thought to function as an inhibitor of h GRalpha activity.

TL;DR: It is suggested that the resistance of the hippocampal BDNF expression to suppression by corticosterone, as seen after water maze training, may contribute to an optimal memory performance.