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Esteban Domingo
Researcher at Spanish National Research Council
Publications - 419
Citations - 29271
Esteban Domingo is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Virus & Viral quasispecies. The author has an hindex of 90, co-authored 405 publications receiving 27897 citations. Previous affiliations of Esteban Domingo include University of California, San Diego & University of Zurich.
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RNA virus mutations and fitness for survival
Esteban Domingo,John J. Holland +1 more
TL;DR: E Epidemiological as well as functional and structural studies suggest that RNA viruses can tolerate restricted types and numbers of mutations during any specific time point during their evolution, which may open new avenues for combating viral infections.
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Viral Quasispecies Evolution
TL;DR: The understanding of viruses as quasispecies has led to new antiviral designs, such as lethal mutagenesis, whose aim is to drive viruses toward low fitness values with limited chances of fitness recovery.
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Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action
María Ángel García,Jesús Gil,Iván Ventoso,Susana Guerra,Esteban Domingo,Carmen Rivas,Mariano Esteban +6 more
TL;DR: A detailed picture is provided on how signaling downstream of PKR unfolds and what are the ultimate consequences of the antiproliferative and antiviral effects exerted by interferons.
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Biological and biomedical implications of the co-evolution of pathogens and their hosts
TL;DR: Improving the understanding of the biomedical significance of co-evolution will require changing the way in which the authors look for it, complementing the phenomenological approach traditionally favored by evolutionary biologists with the exploitation of the extensive data becoming available on the molecular biology and molecular genetics of host–pathogen interactions.