Esther Fernández

TL;DR: A series of diaryl ether substituted 4-pyridones have been identified as having potent antimalarial activity superior to that of chloroquine against Plasmodium falciparum in vitro and murine PlasModium yoelii in vivo through a systematic study of the effects of varying the side chain on activity.

TL;DR: This work has identified 47 starting points for lead optimization by using an agglomerative structural clustering technique followed by computational filters such as antimalarial activity, physicochemical properties, and dissimilarity to known antimalaria structures.

TL;DR: The design, characterization and X-ray structure of a VHL E3 ligase-recruiting Bcl-xL PROTAC degrader reveals an extensive network of neo-interactions, between the E3ligase and the target protein, and between non-cognate parts of the PROTAC and partner proteins.

TL;DR: This TCAMS gametocyte screen provides 276 promising antimalarial molecules with dual asexual/sexual activity, representing starting points for target identification and candidate selection.

TL;DR: A global multilateral collaborative project aimed at screening the significant chemical diversity within the antimalarial in vitro hits described in the literature is a feasible task.