E
Etienne Waelkens
Researcher at Katholieke Universiteit Leuven
Publications - 215
Citations - 8740
Etienne Waelkens is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Phosphatase & Phosphorylation. The author has an hindex of 49, co-authored 212 publications receiving 7747 citations. Previous affiliations of Etienne Waelkens include Ghent University & Catholic University of Leuven.
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Journal ArticleDOI
De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation
Evelien Rysman,Koen Brusselmans,Katryn Scheys,Leen Timmermans,Rita Derua,Sebastian Munck,Paul P. Van Veldhoven,David Waltregny,Veerle W. Daniels,Jelle Machiels,Frank Vanderhoydonc,Karine Smans,Etienne Waelkens,Guido Verhoeven,Johannes V. Swinnen +14 more
TL;DR: Evidence is provided that shifting lipid acquisition from lipid uptake toward de novo lipogenesis dramatically changes membrane properties and protects cells from both endogenous and exogenous insults, and provides a rationale for the use of lipogenesis inhibitors as antineoplastic agents and as chemotherapeutic sensitizers.
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Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice.
Katleen Lemaire,Magalie A. Ravier,Anica Schraenen,John W.M. Creemers,R Van de Plas,Mikaela Granvik,L. Van Lommel,Etienne Waelkens,Fabrice Chimienti,Guy A. Rutter,Patrick Gilon,P. In't Veld,Frans Schuit +12 more
TL;DR: The data show that the ZnT8 transporter is essential for the formation of insulin crystals in beta cells, contributing to the packaging efficiency of stored insulin.
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Identification of the gregarization-associated dark-pigmentotropin in locusts through an albino mutant
Amer I. Tawfik,Seiji Tanaka,Arnold De Loof,Liliane Schoofs,Geert Baggerman,Etienne Waelkens,Rita Derua,Yoram Milner,Yoram Yerushalmi,M. Paul Pener +9 more
TL;DR: Results show that even in isolated (solitary) nymphs, [His7] corazonin induces gregarious black patterns, and its primary structure shows some similarity with the vertebrate melanophore stimulating hormone.
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Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool
Ragna Sannerud,Cary Esselens,Paulina Ejsmont,Rafael Mattera,Leila Rochin,Leila Rochin,Arun Kumar Tharkeshwar,Greet De Baets,Veerle De Wever,Roger Habets,Veerle Baert,Wendy Vermeire,Christine Michiels,Arjan J. Groot,Rosanne Wouters,Katleen Dillen,Katlijn Vints,Pieter Baatsen,Sebastian Munck,Rita Derua,Etienne Waelkens,Guriqbal S. Basi,M Mercken,Marc Vooijs,Mathieu Bollen,Joost Schymkowitz,Frederic Rousseau,Juan S. Bonifacino,Guillaume van Niel,Guillaume van Niel,Bart De Strooper,Bart De Strooper,Wim Annaert +32 more
TL;DR: In this article, the authors examined the significance of this heterogeneity and identified a unique motif in PSEN2 that directs this γ-secretase to late endosomes/lysosomes via a phosphorylationdependent interaction with the AP-1 adaptor complex.
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Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue.
TL;DR: Sequence analysis shows that the novel methyltransferase is distinct from other known protein methyltransferases, sharing only sequence motifs supposedly involved in the binding of adenosylmethionine.