E
Eugene Braunwald
Researcher at Brigham and Women's Hospital
Publications - 1758
Citations - 278949
Eugene Braunwald is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Myocardial infarction & TIMI. The author has an hindex of 230, co-authored 1711 publications receiving 264576 citations. Previous affiliations of Eugene Braunwald include Boston University & University of California, San Francisco.
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Valvular Heart Disease Patients on Edoxaban or Warfarin in the ENGAGE AF-TIMI 48 Trial
Raffaele De Caterina,Giulia Renda,Anthony P. Carnicelli,Francesco Nordio,Marco Trevisan,Michele Mercuri,Christian T. Ruff,Elliott M. Antman,Eugene Braunwald,Robert P. Giugliano +9 more
TL;DR: The presence of VHD increased the risk of death, major adverse cardiovascular events, and major bleeding but did not affect the relative efficacy or safety of higher-dose edoxaban versus warfarin in AF.
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Early initiation of eptifibatide in the emergency department before primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: Results of the Time to Integrilin Therapy in Acute Myocardial Infarction (TITAN)-TIMI 34 trial
C. Michael Gibson,C. Michael Gibson,Ajay J. Kirtane,Sabina A. Murphy,Steve C. Rohrbeck,Venu Menon,Jeffrey Lins,Samer Kazziha,Ivan C. Rokos,Nicolas W. Shammas,Theresa M. Palabrica,Polly Fish,Carolyn H. McCabe,Eugene Braunwald +13 more
TL;DR: A strategy of early initiation of eptifibatide in the ED before primary PCI for STEMI yields superior pre-PCI TIMI frame counts, reflecting epicardial flow, and superior TIMI myocardial perfusion compared with a strategy of initiating ept ifibatides in the CCL without an increase in bleeding risk.
Journal Article
Alpha and beta adrenergic receptor mechanisms in the systemic venous bed
TL;DR: By the use of appropriate adrenergic blocking agents, it was demonstrated that the systemic venous bed contains both beta and alpha adrenergic receptors, and stimulation of either alpha or beta receptors produces venoconstriction.
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Performance of the ABC Scores for Assessing the Risk of Stroke or Systemic Embolism and Bleeding in Patients With Atrial Fibrillation in ENGAGE AF-TIMI 48.
David D. Berg,Christian T. Ruff,Petr Jarolim,Robert P. Giugliano,Francesco Nordio,Hans Lanz,Michele Mercuri,Elliott M. Antman,Eugene Braunwald,David A. Morrow +9 more
TL;DR: The ABC-stroke and ABC-bleeding scores evaluated in this anticoagulated clinical trial cohort were well calibrated and outperformed the CHA2DS2-VASc and HAS-BLED scores, respectively, and may help identify patients most likely to derive a benefit from treatment with non–vitamin K antagonist oral antICOagulants.
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Study design and rationale for the Stabilization of pLaques usIng Darapladib-Thrombolysis in Myocardial Infarction (SOLID-TIMI 52) trial in patients after an acute coronary syndrome
Michelle L. O'Donoghue,Eugene Braunwald,Harvey D. White,Patrick W. Serruys,Ph. Gabriel Steg,Judith S. Hochman,Aldo P. Maggioni,Christoph Bode,Douglas Weaver,Joel L. Johnson,Greg Cicconetti,Mary Ann Lukas,Elizabeth Tarka,Christopher P. Cannon +13 more
TL;DR: The SOLID-TIMI 52 trial will determine the clinical benefit of direct inhibition of Lp-PLA(2) activity with darapladib in patients after an acute coronary syndrome.