Eugene Braunwald

TL;DR: Experiments on isolated cardiac tissue have established that myocardial-fiber shortening is dependent on three factors: the preload, which determines the muscle fiber's end-diastolic length; the co...

TL;DR: In patients with nSTE-ACS managed with standard antithrombotics and an early invasive approach, additional proximal inhibition of the coagulation cascade with rNAPc2 was well tolerated, though some heparin may be necessary to avoid procedure-related thrombus formation.

TL;DR: Regional systolic function and cardiac ultrastructural abnormalities required 7 days for full recovery and Histologic and histochemical analysis did not reveal necrosis at any time, Therefore, biochemical, functional, and ultrastructureural abnormalities induced by brief periods of transient coronary occlusion not associated with necrosis do resolve completely but the recovery period is prolonged.

TL;DR: The reflex tachycardia following hypotension induced by either nitroglycerin or IVCO is mediated by a combination of sympathetic and parasympathetic influences.

TL;DR: This review summarizes the results from recently published pivotal clinical trials for stroke prevention in AF and the treatment and secondary prophylaxis of venous thrombo-embolism and discusses the opportunities as well as uncertainties in the clinical applications of these novel agents.