E
Eugene Zaitsev
Researcher at National Institutes of Health
Publications - 11
Citations - 4517
Eugene Zaitsev is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Receptor tyrosine kinase & Homologous recombination. The author has an hindex of 8, co-authored 11 publications receiving 4155 citations.
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Journal ArticleDOI
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Michael F. Egan,Masami Kojima,Masami Kojima,Joseph H. Callicott,Terry E. Goldberg,Bhaskar Kolachana,Alessandro Bertolino,Eugene Zaitsev,Bert Gold,David Goldman,Michael Dean,Bai Lu,Daniel R. Weinberger +12 more
TL;DR: A role is demonstrated for BDNF and its val/met polymorphism in human memory and hippocampal function and it is suggested val/ met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF.
Journal ArticleDOI
Control of extracellular cleavage of ProBDNF by high frequency neuronal activity
Guhan Nagappan,Eugene Zaitsev,Vladimir V. Senatorov,Jianmin Yang,Barbara L. Hempstead,Bai Lu +5 more
TL;DR: This study demonstrates activity-dependent control of extracellular proteolytic cleavage of a secretory protein, and reveals an important mechanism that controls diametrically opposed functions of BDNF isoforms.
Journal ArticleDOI
Sorting and Activity-Dependent Secretion of BDNF Require Interaction of a Specific Motif with the Sorting Receptor Carboxypeptidase E
TL;DR: A mechanism whereby a specific motif I(16)E(18)I(105)D(106) interacts with CPE to sort proBDNF into regulated pathway vesicles for activity-dependent secretion is identified.
Journal ArticleDOI
Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival
Hisatsugu Koshimizu,Kazuyuki Kiyosue,Tomoko Hara,Shunsuke Hazama,Shunsuke Hazama,Shingo Suzuki,Koichi Uegaki,Guhan Nagappan,Eugene Zaitsev,Takatsugu Hirokawa,Yoshiro Tatsu,Akihiko Ogura,Bai Lu,Masami Kojima +13 more
TL;DR: Interestingly, in marked contrast to the action of matBDNF, CR-proBDNF dramatically reduced the number of cholinergic fibers and hippocampal dendritic spines, without affecting the survival of these neurons.
Cleavage of proBDNF by tPA/ Plasmin Is Essential for Long-Term
Petti T. Pang,Henry K. Teng,Eugene Zaitsev,Newton T. Woo,Kazuko Sakata,Shushuang Zhen,Kenneth K. Teng,Wing-Ho Yung,Barbara L. Hempstead,Bai Lu +9 more
TL;DR: It is reported that tPA, by activating the extracellular protease plasmin, converts the precursor proBDNF to the mature BDNF (mBDNF), and that such conversion is critical for L-LTP expression in mouse hippocampus.