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Eun Young Kim

Bio: Eun Young Kim is an academic researcher from Chung-Ang University. The author has contributed to research in topics: Internal medicine & Oocyte. The author has an hindex of 27, co-authored 309 publications receiving 3000 citations. Previous affiliations of Eun Young Kim include Kyushu University & Chungnam National University.


Papers
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Journal ArticleDOI
TL;DR: EIGP subjects have higher reward dependency and an increased prevalence of the DRD2 Taq1A1 and COMTL alleles, which seems to be associated with reward dependence in EIGP adolescents.
Abstract: :Excessive internet video game play (EIGP) has emerged as a leading cause of behavioral and developmental problems in adolescents. Recent research has implicated the role of striatal dopaminergic system in the behavioral maladaptations associated with EIGP. This study investigates the reward

200 citations

Journal ArticleDOI
07 Jun 2012-Trials
TL;DR: Improvements in the quality of RCT reports can be expected by adhering to existing standards and guidelines as expressed by the CONSORT group, especially in the methodological quality domains.
Abstract: The extended Consolidated Standards of Reporting Trials (CONSORT) Statement for Abstracts was developed to improve the quality of reports of randomized controlled trials (RCTs) because readers often base their assessment of a trial solely on the abstract. To date, few data exist regarding whether it has achieved this goal. We evaluated the extent of adherence to the CONSORT for Abstract statement for quality of reports on RCT abstracts by four high-impact general medical journals. A descriptive analysis of published RCT abstracts in The New England Journal of Medicine (NEJM), The Lancet, The Journal of American Medical Association (JAMA), and the British Medical Journal (BMJ) in the year 2010 was conducted by two reviewers, independently extracting data from a MEDLINE/PubMed search. We identified 271 potential RCT abstracts meeting our inclusion criteria. More than half of the abstracts identified the study as randomized in the title (58.7%; 159/271), reported the specific objective/hypothesis (72.7%; 197/271), described participant eligibility criteria with settings for data collection (60.9%; 165/271), detailed the interventions for both groups (90.8%; 246/271), and clearly defined the primary outcome (94.8%; 257/271). However, the methodological quality domains were inadequately reported: allocation concealment (11.8%; 32/271) and details of blinding (21.0%; 57/271). Reporting the primary outcome results for each group was done in 84.1% (228/271). Almost all of the abstracts reported trial registration (99.3%; 269/271), whereas reports of funding and of harm or side effects from the interventions were found in only 47.6% (129/271) and 42.8% (116/271) of the abstracts, respectively. These findings show inconsistencies and non-adherence to the CONSORT for abstract guidelines, especially in the methodological quality domains. Improvements in the quality of RCT reports can be expected by adhering to existing standards and guidelines as expressed by the CONSORT group.

120 citations

Journal ArticleDOI
TL;DR: In this paper, the effects of including critical care pharmacists in multidisciplinary ICU teams on clinical outcomes including mortality, ICU length of stay, and adverse drug events were assessed.
Abstract: Objectives:The objective of this systematic review and meta-analysis was to assess the effects of including critical care pharmacists in multidisciplinary ICU teams on clinical outcomes including mortality, ICU length of stay, and adverse drug events.Data Sources:PubMed, EMBASE, and references from

104 citations

Journal ArticleDOI
01 May 2006-Zygote
TL;DR: The results indicate that the cryopreservation procedure might cause damage that results in an increase in DNA fragmentation and apoptosis-related gene transcription, reducing developmental capacity of frozen-thawed embryos.
Abstract: Evaluation of apoptosis and expression level of apoptosis-related genes is useful for examining the variation in embryo quality according to environmental change The objective of this study was to investigate DNA fragmentation and apoptosis-related gene expression patterns in frozen-thawed bovine blastocysts In vitro produced day 7 blastocysts were frozen by two different vitrification methods (conventional 025 ml straw or MVC straw) After thawing, DNA fragmentation of surviving embryos was examined by TUNEL assay, and the expression patterns of their apoptotic genes (survivin, Fas, Hsp 70 and caspase-3) were evaluated using real-time quantitative reverse transcriptase polymerase chain reaction In vitro survival rates of frozen-thawed embryos were higher following the MVC vitrification method (882% re-expanded at 24 h, 771% hatching at 48 h) than the conventional (C) vitrification method (770% re-expanded at 24 h, 667% hatching at 48 h) However, both vitrified methods resulted in a significantly higher apoptotic index (C vitrification method 119%, MVC vitrification method 110%) than in non-frozen embryos (30%) Expression levels of survivin, Fas, caspase-3, and Hsp 70 were also increased in the frozen-thawed embryos compared with non-frozen embryos These results indicate that the cryopreservation procedure might cause damage that results in an increase in DNA fragmentation and apoptosis-related gene transcription, reducing developmental capacity of frozen-thawed embryos

102 citations

Journal ArticleDOI
TL;DR: The use of CT-guided aspiration and core biopsy resulted in a high diagnostic yield for pulmonary nodules smaller than 1 cm, and the use of the aspiration method alone was an independent risk factor associated with diagnostic failure.
Abstract: OBJECTIVE. We conducted a retrospective analysis to evaluate the diagnostic outcomes of CT-guided aspiration and core biopsy of 305 pulmonary nodules measuring less than 1 cm. MATERIALS AND METHODS. We determined the diagnostic yield of using CT-guided aspiration and core biopsy to analyze 305 lesions in 290 patients. Diagnostic performance was evaluated according to the biopsy method, including aspiration alone, core biopsy alone, and combination use, and the consistency of the nodule, including solid, partly solid ground-glass opacity (GGO), and pure GGO. Final diagnoses were established in 268 of the 305 lesions (87.9%). Nondiagnostic biopsy results were obtained for 27 of the 268 lesions (10.1%). RESULTS. The overall sensitivity, specificity, positive predictive value, and negative predictive value for the diagnosis of malignancy were 93.1% (148 of 159 lesions), 98.8% (81/82), 99.3% (148/149), and 88.0% (81/92), respectively; diagnostic accuracy was 95.0% (229/241). Using multivariate logistic regress...

83 citations


Cited by
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01 Sep 2008
TL;DR: The Methodology used to Prepare the Guideline Epidemiology Incidence Etiology and Recommendations for Assessing Response to Therapy Suggested Performance Indicators is summarized.
Abstract: Executive Summary Introduction Methodology Used to Prepare the Guideline Epidemiology Incidence Etiology Major Epidemiologic Points Pathogenesis Major Points for Pathogenesis Modifiable Risk Factors Intubation and Mechanical Ventilation Aspiration, Body Position, and Enteral Feeding Modulation of Colonization: Oral Antiseptics and Antibiotics Stress Bleeding Prophylaxis, Transfusion, and Glucose Control Major Points and Recommendations for Modifiable Risk Factors Diagnostic Testing Major Points and Recommendations for Diagnosis Diagnostic Strategies and Approaches Clinical Strategy Bacteriologic Strategy Recommended Diagnostic Strategy Major Points and Recommendations for Comparing Diagnostic Strategies Antibiotic Treatment of Hospital-acquired Pneumonia General Approach Initial Empiric Antibiotic Therapy Appropriate Antibiotic Selection and Adequate Dosing Local Instillation and Aerosolized Antibiotics Combination versus Monotherapy Duration of Therapy Major Points and Recommendations for Optimal Antibiotic Therapy Specific Antibiotic Regimens Antibiotic Heterogeneity and Antibiotic Cycling Response to Therapy Modification of Empiric Antibiotic Regimens Defining the Normal Pattern of Resolution Reasons for Deterioration or Nonresolution Evaluation of the Nonresponding Patient Major Points and Recommendations for Assessing Response to Therapy Suggested Performance Indicators

2,961 citations

Journal ArticleDOI
TL;DR: Recent progress on drug metabolism activity profiles, interindividual variability and regulation of expression, and the functional and clinical impact of genetic variation in drug metabolizing P450s are reviewed.

2,832 citations